Eric. Hesse, et.al., Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity., The Journal of cell biology, 2010, 191

http://rdf.ncbi.nlm.nih.gov/pubmed/21173110

Eric. Hesse, et.al., Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity., The Journal of cell biology, 2010, 191

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Zfp521<tm2Ngc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887921
• Tg(Col1a1-Runx2)#Pmt
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887925
• Tg(Eno2tTA)#Nes
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887904

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased bone volume_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0010875IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• abnormal hyoid bone morphology_Runx2<tm1Mjo>/Runx2<+>
  http://metadb.riken.jp/0003056NSRunx2tm1MjoRunx2Runx2tm1MjoRunx2
• increased osteoblast cell number_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0004988IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• abnormal bone mineralization_Tg(Col1a1-Runx2)#Pmt/0,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0002896IBALBcC57BL6SJLTgCol1a1Runx2Pmt0TgEno2tTANes0TgtetOZfp521Rbar0TgEno2tTANesTgCol1a1Runx2PmtTgtetOZfp521Rbar
• abnormal trabecular bone morphology_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0000130IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• abnormal osteocyte morphology_Tg(Col1a1-Runx2)#Pmt/0,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0008753IBALBcC57BL6SJLTgCol1a1Runx2Pmt0TgEno2tTANes0TgtetOZfp521Rbar0TgEno2tTANesTgCol1a1Runx2PmtTgtetOZfp521Rbar
• clavicle hypoplasia_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0004337IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• increased hyoid bone size_Zfp521<tm2Ngc>/Zfp521<+>
  http://metadb.riken.jp/0009911NSZfp521tm2NgcZfp521Zfp521Zfp521tm2Ngc
• decreased hyoid bone size_Runx2<tm1Mjo>/Runx2<+>,Zfp521<tm2Ngc>/Zfp521<+>
  http://metadb.riken.jp/0009912NSRunx2tm1MjoRunx2Zfp521tm2NgcZfp521Runx2Runx2tm1MjoZfp521Zfp521tm2Ngc
• abnormal bone mineralization_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0002896IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• clavicle hypoplasia_Runx2<tm1Mjo>/Runx2<+>,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0004337IC57BL6SJLRunx2tm1MjoRunx2TgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarRunx2Runx2tm1MjoTgEno2tTANes
• abnormal osteocyte morphology_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0008753IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• clavicle hypoplasia_Runx2<tm1Mjo>/Runx2<+>,Zfp521<tm2Ngc>/Zfp521<+>
  http://metadb.riken.jp/0004337NSRunx2tm1MjoRunx2Zfp521tm2NgcZfp521Runx2Runx2tm1MjoZfp521Zfp521tm2Ngc
• abnormal fontanelle morphology_Runx2<tm1Mjo>/Runx2<+>,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0000084IC57BL6SJLRunx2tm1MjoRunx2TgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarRunx2Runx2tm1MjoTgEno2tTANes
• decreased compact bone thickness_Tg(Col1a1-Runx2)#Pmt/0,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0000135IBALBcC57BL6SJLTgCol1a1Runx2Pmt0TgEno2tTANes0TgtetOZfp521Rbar0TgEno2tTANesTgCol1a1Runx2PmtTgtetOZfp521Rbar
• abnormal bone ossification_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0008271IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• abnormal fontanelle morphology_Runx2<tm1Mjo>/Runx2<+>
  http://metadb.riken.jp/0000084NSRunx2tm1MjoRunx2Runx2tm1MjoRunx2
• abnormal clavicle morphology_Zfp521<tm2Ngc>/Zfp521<+>
  http://metadb.riken.jp/0005298NSZfp521tm2NgcZfp521Zfp521Zfp521tm2Ngc
• increased osteoclast cell number_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0004984IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• fragile skeleton_Tg(Col1a1-Runx2)#Pmt/0,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0000061IBALBcC57BL6SJLTgCol1a1Runx2Pmt0TgEno2tTANes0TgtetOZfp521Rbar0TgEno2tTANesTgCol1a1Runx2PmtTgtetOZfp521Rbar
• increased bone mass_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0005605IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• fragile skeleton_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0000061IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• decreased hyoid bone size_Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0009912IC57BL6SJLTgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarTgEno2tTANes
• abnormal osteoblast differentiation_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0008395IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• clavicle hypoplasia_Runx2<tm1Mjo>/Runx2<+>
  http://metadb.riken.jp/0004337NSRunx2tm1MjoRunx2Runx2tm1MjoRunx2
• decreased compact bone thickness_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0000135IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• abnormal compact bone morphology_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0003797IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• decreased bone mass_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0004016IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• abnormal bone ossification_Tg(Col1a1-Runx2)#Pmt/0
  http://metadb.riken.jp/0008271IBALBcC57BL6TgCol1a1Runx2Pmt0TgCol1a1Runx2Pmt
• abnormal hyoid bone morphology_Runx2<tm1Mjo>/Runx2<+>,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
  http://metadb.riken.jp/0003056IC57BL6SJLRunx2tm1MjoRunx2TgEno2tTANes0TgtetOZfp521Rbar0TgtetOZfp521RbarRunx2Runx2tm1MjoTgEno2tTANes

class

http://purl.org/net/cito/citesAsAuthority

• Zfp521<tm2Ngc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887921
• Tg(Col1a1-Runx2)#Pmt
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887925
• Tg(Eno2tTA)#Nes
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887904

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD21254
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD21254
• CD03203
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03203
• CD32031
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD32031
• CD12944
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12944