Michael R. Hughes, et.al., A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis., Experimental hematology, 2011, 39

http://rdf.ncbi.nlm.nih.gov/pubmed/21193012

Michael R. Hughes, et.al., A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis., Experimental hematology, 2011, 39

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ank1<M1Wlst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947988

class

http://purl.org/net/cito/citesAsAuthority

• Ank1<M1Wlst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4947988

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased birth weight_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0009674I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased hemoglobin content_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002874IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• postnatal lethality, incomplete penetrance_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0011086I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• polychromatophilia_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0005097I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• increased erythrocyte cell number_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0003131IC3HHeJC57BL6Ank1M1WlstAnk1Ank1M1WlstAnk1
• preweaning lethality, complete penetrance_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0011100C3B6Ank1M1WlstAnk1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased cellular hemoglobin content_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0008956C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• premature death_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002083I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• abnormal leukocyte cell number_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000217IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• jaundice_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000611I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased hematocrit_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000208IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• abnormal erythrocyte morphology_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0002447I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1Ank1M1WlstAnk1
• decreased common myeloid progenitor cell number_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0008813I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased cellular hemoglobin content_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0008956IC3HHeJC57BL6Ank1M1WlstAnk1Ank1M1WlstAnk1
• polychromatophilia_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0005097C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• gallstones_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002830I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• enlarged spleen_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000691I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• increased erythrocyte cell number_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0003131IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased body size_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0001265I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased body weight_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0001262I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased mean corpuscular hemoglobin concentration_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0005642IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• hemolytic anemia_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0001585I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased hematocrit_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000208I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• enlarged heart_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000274I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• increased erythrocyte cell number_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0003131C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• decreased mean corpuscular volume_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002591IC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• increased nucleated erythrocyte cell number_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0009395I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• abnormal common myeloid progenitor cell morphology_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0006410I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• postnatal growth retardation_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0001732I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased mean corpuscular volume_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0002591IC3HHeJC57BL6Ank1M1WlstAnk1Ank1M1WlstAnk1
• increased erythroid progenitor cell number_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0003135I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• erythroblastosis_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0005096I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• decreased mean corpuscular volume_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0002591C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• abnormal myelopoiesis_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0001601I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• reticulocytosis_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0002640C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• spherocytosis_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002812I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• abnormal erythrocyte osmotic lysis_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0003657C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• decreased mean corpuscular hemoglobin concentration_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0005642C3B6Ank1M1WlstAnk1M1WlstAnk1Ank1M1WlstAnk1
• decreased fetal weight_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0009431I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• pallor_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0003717I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• extramedullary hematopoiesis_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0000240I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• reticulocytosis_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002640I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst
• enlarged spleen_Ank1<M1Wlst>/Ank1<+>
  http://metadb.riken.jp/0000691I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1Ank1M1WlstAnk1
• abnormal erythrocyte morphology_Ank1<M1Wlst>/Ank1<M1Wlst>
  http://metadb.riken.jp/0002447I129S1SvImJC3HHeJC57BL6Ank1M1WlstAnk1M1WlstAnk1M1Wlst