Gerry P. Crossan, et.al., Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia., Nature genetics, 2011, 43

http://rdf.ncbi.nlm.nih.gov/pubmed/21240276

Gerry P. Crossan, et.al., Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia., Nature genetics, 2011, 43

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased leukocyte cell number_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000221C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal cranium morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000438C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• enlarged cranium_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000439C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• domed cranium_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000440C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal cerebral cortex morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000788C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• dilated lateral ventricles_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000825C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
他42件を見る
• abnormal third ventricle morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000826C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• obstructive hydrocephaly_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0000917C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• absent mature ovarian follicles_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001132C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• absent corpus luteum_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001134C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal spermatogenesis_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001156C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• decreased body weight_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001262C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• decreased body size_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001265C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• anophthalmia_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001293C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• microphthalmia_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001297C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal cornea morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001312C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• corneal opacity_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001314C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal pupil morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001317C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal iris morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001322C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• absent optic nerve_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001333C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• postnatal growth retardation_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001732C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• hydroencephaly_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001891C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• reduced male fertility_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001922C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• reduced female fertility_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001923C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• decreased litter size_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001935C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal eye morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0002092C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal tooth morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0002100C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal lymphopoiesis_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0002401C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• oligozoospermia_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0002687C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal retinal vasculature morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0002792C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• increased erythrocyte cell number_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0003131C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• thrombocytopenia_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0003179C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal eyelid aperture_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0003671C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal spine curvature_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0004174C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• vertebral fusion_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0004609C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• absent oocytes_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0004805C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• azoospermia_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0005159C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• impaired glucose tolerance_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0005293C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• increased circulating glucose level_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0005559C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• thin cerebral cortex_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0006254C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• early cellular replicative senescence_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008008C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal male germ cell apoptosis_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008280C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• abnormal primordial germ cell morphology_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008391C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• decreased common myeloid progenitor cell number_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008813C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• chromosomal instability_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008866C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• increased caudal vertebrae number_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0010102C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• perinatal lethality, incomplete penetrance_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0011090C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• lethality throughout fetal growth and development, incomplete penetrance_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0011109C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00487
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00487