Madeleine R. Brouns, et.al., Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse., Human molecular genetics, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21262862

Madeleine R. Brouns, et.al., Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse., Human molecular genetics, 2011, 20

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• failure of eyelid fusion_Axd/Axd
  http://metadb.riken.jp/0009264IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• abnormal embryo development_Axd/Axd
  http://metadb.riken.jp/0001672IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• embryonic lethality during organogenesis, complete penetrance_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0011098I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• exencephaly_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0000914I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• exencephaly_Grhl2<Gt(AC0205)Wtsi>/Grhl2<+>
  http://metadb.riken.jp/0000914I129P2OlaHsdC57BL6Grhl2GtAC0205WtsiGrhl2Grhl2GtAC0205WtsiGrhl2
• delayed eyelid fusion_Axd/Axd
  http://metadb.riken.jp/0009265IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• abnormal caudal neuropore morphology_Axd/Axd<+>
  http://metadb.riken.jp/0012544IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxdAxd
• facial cleft_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0008797I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• decreased cell proliferation_Axd/Axd
  http://metadb.riken.jp/0000352IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• delayed neural tube closure_Axd/Axd<+>
  http://metadb.riken.jp/0002621IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxdAxd
• facial cleft_Grhl2<Gt(AC0205)Wtsi>/Grhl2<+>
  http://metadb.riken.jp/0008797I129P2OlaHsdC57BL6Grhl2GtAC0205WtsiGrhl2Grhl2GtAC0205WtsiGrhl2
• abnormal caudal neuropore morphology_Axd/Axd
  http://metadb.riken.jp/0012544IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• embryonic lethality during organogenesis, complete penetrance_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• vestigial tail_Axd/Axd
  http://metadb.riken.jp/0002632IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• abnormal neural tube closure_Axd/Axd
  http://metadb.riken.jp/0003720IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• curly tail_Axd/Axd<+>
  http://metadb.riken.jp/0003051IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxdAxd
• curly tail_Axd/Axd<+>,Grhl3<ct>/Grhl3<+>
  http://metadb.riken.jp/0003051IBALBcC3HHeNC57BL6GFFAxdAxdGrhl3ctGrhl3AxdAxdGrhl3Grhl3ct
• incomplete rostral neuropore closure_Grhl2<Gt(AC0205)Wtsi>/Grhl2<+>
  http://metadb.riken.jp/0000928I129P2OlaHsdC57BL6Grhl2GtAC0205WtsiGrhl2Grhl2GtAC0205WtsiGrhl2
• abnormal neural tube closure_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0003720I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• incomplete rostral neuropore closure_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0000928I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• spina bifida_Grhl2<Gt(AC0205)Wtsi>/Grhl2<Gt(AC0205)Wtsi>
  http://metadb.riken.jp/0003054I129P2OlaHsdBALBcC57BL6Grhl2GtAC0205WtsiGrhl2GtAC0205WtsiGrhl2GtAC0205Wtsi
• spina bifida cystica_Axd/Axd
  http://metadb.riken.jp/0012547IBALBcBALBcAnNCrlC3HHeNC57BL6AxdAxdAxd
• abnormal caudal neuropore morphology_Axd/Axd<+>,Grhl2<Gt(AC0205)Wtsi>/Grhl2<+>
  http://metadb.riken.jp/0012544I129P2OlaHsdBALBcC3HHeNC57BL6AxdAxdGrhl2GtAC0205WtsiGrhl2Grhl2GtAC0205WtsiGrhl2AxdAxd
• delayed neural tube closure_Axd/Axd<+>,Grhl2<Gt(AC0205)Wtsi>/Grhl2<+>
  http://metadb.riken.jp/0002621I129P2OlaHsdBALBcC3HHeNC57BL6AxdAxdGrhl2GtAC0205WtsiGrhl2Grhl2GtAC0205WtsiGrhl2AxdAxd