Raul M. Luque, et.al., Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes., PloS one, 2011, 6

http://rdf.ncbi.nlm.nih.gov/pubmed/21283519

Raul M. Luque, et.al., Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes., PloS one, 2011, 6

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased retroperitoneal fat pad weight_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0009304IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased somatotroph cell number_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0008329IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• abnormal circulating hormone level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005418IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• increased circulating leptin level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005669IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased circulating growth hormone level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005120IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased circulating glucose level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005560IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased oxygen consumption_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005290IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• increased insulin sensitivity_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0002891IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• abnormal energy expenditure_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005450IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased fluid intake_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0011942IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• impaired glucose tolerance_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0005293IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased circulating insulin-like growth factor I level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0004701IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• abnormal glucose homeostasis_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0002078IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased liver weight_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0003402IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased energy expenditure_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0004890IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• increased respiratory quotient_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0010378IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• abnormal gas homeostasis_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0003948IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased body weight_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0001262IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• increased total body fat amount_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0010024IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• small adenohypophysis_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0008321IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased liver triglyceride level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0009356IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• increased subcutaneous adipose tissue amount_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0010934IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased circulating insulin level_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0002727IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai
• decreased lean body mass_Gt(ROSA)26Sor<tm1(HBEGF)Awai>/Gt(ROSA)26Sor<+>,Tg(Gh1-cre)bKnmn/0
  http://metadb.riken.jp/0003961IC57BL6FVBNGtROSA26Sortm1HBEGFAwaiGtROSA26SorTgGh1crebKnmn0GtROSA26SorTgGh1crebKnmnGtROSA26Sortm1HBEGFAwai