Sandra. Gardam, et.al., Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response., Blood, 2011, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/21300983

Sandra. Gardam, et.al., Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response., Blood, 2011, 117

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Birc3<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013652
• Birc2<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013654
• Birc3<tm1.1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013655

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B cell apoptosis_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008783I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• increased follicular B cell number_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008173I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• enlarged lymph nodes_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000702I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• abnormal B cell differentiation_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>
  http://metadb.riken.jp/0002144I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfrsf13ctm1MassTnfrsf13ctm1MassCd19Tnfrsf13ctm1MassCd19tm1creCgn
• increased B cell number_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• decreased germinal center B cell number_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008178I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• increased marginal zone B cell number_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008181I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• enlarged spleen_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr
• decreased germinal center B cell number_Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008178IC57BL6Tnfrsf13ctm1MassTnfrsf13ctm1MassTraf2tm1RbrTraf2tm1RbrTnfrsf13ctm1MassTraf2tm1Rbr
• decreased spleen germinal center size_Tnfrsf13c<tm1Mass>/Tnfrsf13c<tm1Mass>,Traf2<tm1Rbr>/Traf2<tm1Rbr>
  http://metadb.riken.jp/0008484IC57BL6Tnfrsf13ctm1MassTnfrsf13ctm1MassTraf2tm1RbrTraf2tm1RbrTnfrsf13ctm1MassTraf2tm1Rbr
• decreased spleen germinal center size_Birc2<tm1Rbr>/Birc2<tm1Rbr>,Birc3<tm1.1Rbr>/Birc3<tm1.1Rbr>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008484I129P2OlaHsdC57BL6NZBBirc2tm1RbrBirc2tm1RbrBirc3tm11RbrBirc3tm11RbrCd19tm1creCgnCd19Birc2tm1RbrCd19tm1creCgnCd19Birc3tm11Rbr

class

http://purl.org/net/cito/citesAsAuthority

• Birc3<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013652
• Birc2<tm1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013654
• Birc3<tm1.1Rbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5013655