Xue. Wu, et.al., MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21339642

Xue. Wu, et.al., MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Raf1<tm1.1Bgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5003364

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged heart right atrium_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0008727I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• cardiac fibrosis_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0003141I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased response of heart to induced stress_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0004485I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• abnormal cardiovascular system physiology_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001544I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased leukocyte cell number_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000218I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased neutrophil cell number_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000219I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased sensitivity to induced morbidity/mortality_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0009763I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased heart weight_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0002833I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• enlarged myocardial fiber_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0004564I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• dilated cardiomyopathy_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0002795I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased cardiac stroke volume_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0011951I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• abnormal facial morphology_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0003743I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• cardiac hypertrophy_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001625I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased cranium width_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000441I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• enlarged spleen_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• ocular hypertelorism_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001300I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• decreased cardiac muscle contractility_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0005140I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• decreased body weight_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001262I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased heart left ventricle size_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0010579I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• decreased cranium height_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0008525I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased heart ventricle size_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0008772I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• thick interventricular septum_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0010724I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• abnormal common myeloid progenitor cell morphology_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0006410I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• abnormal snout morphology_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000443I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased left ventricle systolic pressure_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0003820I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• thick ventricular wall_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0002953I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased cardiac output_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0003394I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• abnormal heart left ventricle pressure_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0010754I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• decreased body length_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001258I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased cardiac muscle contractility_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0005599I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• decreased body size_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• increased monocyte cell number_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0000220I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1
• cardiac interstitial fibrosis_Raf1<tm1.1Bgn>/Raf1<+>
  http://metadb.riken.jp/0005608I129S6SvEvTacC57BL6NCrRaf1tm11BgnRaf1Raf1tm11BgnRaf1

class

http://purl.org/net/cito/citesAsAuthority

• Raf1<tm1.1Bgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5003364