Jelena. Urosevic, et.al., Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21383153

Jelena. Urosevic, et.al., Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946645

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cataract_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001304I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal immune system physiology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001790B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• cataract_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001304I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• premature death_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002083B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal kidney morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002135B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• decreased body size_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• increased thymocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009541B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal pancreatic acinar cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009146B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal pancreatic acinar cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009146I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased body size_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal basicranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0010029I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal skin sebaceous gland morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009535B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• postnatal lethality, incomplete penetrance_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0011086I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal dermal melanocyte morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009386I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal frontal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000107B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• decreased thymocyte number_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000715I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal mating frequency_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001377I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal kidney morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002135I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal immune system physiology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001790I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal parietal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000109B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• increased gland tumor incidence_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0010288I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal neurocranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000074I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• decreased body weight_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased thymocyte number_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000715I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• decreased body weight_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal neurocranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000074B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• thymus atrophy_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0003644I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• thymus atrophy_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0003644B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• decreased white adipose tissue amount_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001783I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• premature death_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000358B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• increased lung adenoma incidence_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002048I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased white adipose tissue amount_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001783I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000358I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal thymus morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000703I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• enlarged heart_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal thymus morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000703B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal frontal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000107I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal skin sebaceous gland morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009535I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal mating frequency_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001377B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• tachypnea_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0005426I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal immune system physiology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001790I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal skin sebaceous gland morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009535I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal parietal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000109I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• increased metastatic potential_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001272I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• increased pheochromocytoma incidence_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002050I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• increased splenocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009322I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000358I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• increased circulating noradrenaline level_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0005665I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal thymus morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000703I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal parietal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000109I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• hyperactivity_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001399I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• hyperactivity_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001399I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal pancreatic acinar cell morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009146I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• abnormal basicranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0010029B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• increased splenocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009322I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal astrocyte morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002182I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• convulsive seizures_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000947I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• enlarged heart_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• decreased creatinine clearance_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0005558B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal head morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000432I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• heart hyperplasia_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000275I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• premature death_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• increased thymocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009541I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal basicranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0010029I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• decreased white adipose tissue amount_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001783B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal frontal bone morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000107I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• increased splenocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009322B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal mating frequency_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001377I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal head shape_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0011495B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• cataract_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001304B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• enlarged heart_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000274B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• increased cardiac muscle contractility_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0005599I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased body size_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001265B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal head morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000432I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• increased thymocyte apoptosis_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0009541I129S1Sv129X1SvJC57BL6JBraftm1BbdBrafBrafBraftm1Bbd
• oliguria_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0003620B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• hyperactivity_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001399B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• thymus atrophy_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0003644I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• abnormal kidney morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0002135I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased thymocyte number_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000715B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf
• abnormal neurocranium morphology_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0000074I129S1Sv129X1SvJC57BL6JCD1Braftm1BbdBrafBrafBraftm1Bbd
• decreased body weight_Braf<tm1Bbd>/Braf<+>
  http://metadb.riken.jp/0001262B6129Braftm1BbdBraftm1BbdBrafBraftm1BbdBraf

class

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1Bbd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946645