Yankun. Gao, et.al., DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair., Nature, 2011, 471

http://rdf.ncbi.nlm.nih.gov/pubmed/21390131

Yankun. Gao, et.al., DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair., Nature, 2011, 471

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lig3<tm1.1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946931

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal neuron differentiation_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009937IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal myocardial fiber morphology_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0000278IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• abnormal astrocyte morphology_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002182IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• premature death_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002083IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• abnormal cardiovascular system physiology_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001544IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• abnormal astrocyte physiology_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008916IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal cellular respiration_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010954IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal neuronal precursor proliferation_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004948IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• dilated heart atrium_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0003140IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• dilated heart ventricle_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0008022IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• postnatal growth retardation_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001732IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• ataxia_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal DNA repair_Xrcc1<tm1Pmc>/Xrcc1<tm1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008058I129S1SvFVBNXrcc1tm1PmcXrcc1tm1PmcTgNescre1Kln0TgNescre1KlnXrcc1tm1Pmc
• abnormal DNA repair_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008058IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• decreased cardiac muscle contractility_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0005140IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• decreased oligodendrocyte number_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009808IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• postnatal lethality, complete penetrance_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011085IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• decreased brain size_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• microcephaly_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000433IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal DNA repair_Aptx<tm1Pmc>/Aptx<tm1Pmc>
  http://metadb.riken.jp/0008058NSAptxtm1PmcAptxtm1PmcAptxtm1Pmc
• abnormal DNA repair_Tdp1<Gt(XD105)Byg>/Tdp1<Gt(XD105)Byg>
  http://metadb.riken.jp/0008058I129P2OlaHsdTdp1GtXD105BygTdp1GtXD105BygTdp1GtXD105Byg
• decreased cerebellar granule cell number_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008924IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• abnormal cerebellum development_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000854IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• enlarged heart_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0000274IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc
• small cerebellum_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000852IC57BL6SJLLig3tm11PmcLig3tm11PmcTgNescre1Kln0Lig3tm11PmcTgNescre1Kln
• thin ventricular wall_Lig3<tm1.1Pmc>/Lig3<tm1.1Pmc>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0000280IC57BL6FVBLig3tm11PmcLig3tm11PmcTgCkmmcre5Khn0TgCkmmcre5KhnLig3tm11Pmc

class

http://purl.org/net/cito/citesAsAuthority

• Lig3<tm1.1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4946931

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD15510
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15510
• CD10266
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD10266