Jochen A. Ackermann, et.al., Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling., The EMBO journal, 2011, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/21427701

Jochen A. Ackermann, et.al., Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling., The EMBO journal, 2011, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Grb2<tm1.1Lnit>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568397
• Grb2<tm1Lnit>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4949889

class

http://purl.org/net/cito/citesAsAuthority

• Grb2<tm1.1Lnit>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568397
• Grb2<tm1Lnit>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4949889

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal B cell differentiation_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002144IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased transitional stage T2 B cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0009926IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• increased B cell apoptosis_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008782IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased mature B cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008211IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased IgG3 level_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008498IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• increased IgM level_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002494IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased transitional stage T1 B cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0009923IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased B cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005017IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased IgG level_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0001805IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• increased B cell proliferation_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0005154IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• abnormal B cell physiology_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002459IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• increased plasma cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008097IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased spleen germinal center number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008482IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased follicular B cell number_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008174IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• decreased spleen germinal center size_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008484IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth
• abnormal memory B cell physiology_Grb2<tm1Lnit>/Grb2<tm1Lnit>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008194IBALBcBALBcJGrb2tm1LnitGrb2tm1LnitCd79atm1creRethCd79aCd79aGrb2tm1LnitCd79atm1creReth