Lixiang. Wang, et.al., Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice., The Journal of biological chemistry, 2011, 286

http://rdf.ncbi.nlm.nih.gov/pubmed/21464123

Lixiang. Wang, et.al., Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice., The Journal of biological chemistry, 2011, 286

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad2<tm1.1Nomu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085284

class

http://purl.org/net/cito/citesAsAuthority

• Smad2<tm1.1Nomu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5085284

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal Purkinje cell dendrite morphology_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008572IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal gait_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001406IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• premature death_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002083IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• decreased body size_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001265IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellar granule cell morphology_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004098IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellar granule cell migration_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009977IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• tremors_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000745IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellum morphology_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000849IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• limb grasping_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001513IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellum vermis lobule X morphology_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009997IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• ataxia_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001393IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• short stride length_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001407IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal posture_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001504IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• slow postnatal weight gain_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008489IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• impaired balance_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001525IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellum vermis lobule IX morphology_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009992IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal cerebellar foliation_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000857IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• increased neuron apoptosis_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003203IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• abnormal locomotor coordination_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003312IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln
• decreased CNS synapse formation_Smad2<tm1.1Nomu>/Smad2<tm1.1Nomu>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004998IC57BL6SJLSmad2tm11NomuSmad2tm11NomuTgNescre1Kln0Smad2tm11NomuTgNescre1Kln