Takashi. Sekiya, et.al., The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells., Nature communications, 2011, 2

http://rdf.ncbi.nlm.nih.gov/pubmed/21468021

Takashi. Sekiya, et.al., The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells., Nature communications, 2011, 2

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nr4a1<tm1Pcn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5546594

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased T-helper 1 cell number_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0008086NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal regulatory T cell morphology_Nr4a2<tm1.1Pcn>/Nr4a2<+>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0004941I129S1Sv129X1SvJNr4a2tm11PcnNr4a2Foxp3tm4YFPicreAyrFoxp3Nr4a2Nr4a2tm11PcnFoxp3Foxp3tm4YFPicreAyr
• neonatal lethality, incomplete penetrance_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0011088NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal regulatory T cell morphology_Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>,Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>
  http://metadb.riken.jp/0004941I129S1Sv129X1SvJFoxp3tm4YFPicreAyrFoxp3Nr4a2tm11PcnNr4a2tm11PcnNr4a2tm11PcnFoxp3Foxp3tm4YFPicreAyr
• increased susceptibility to induced colitis_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0008537NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal T-helper 1 cell differentiation_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0008088NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal regulatory T cell physiology_Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>,Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>
  http://metadb.riken.jp/0004946I129S1Sv129X1SvJFoxp3tm4YFPicreAyrFoxp3Nr4a2tm11PcnNr4a2tm11PcnNr4a2tm11PcnFoxp3Foxp3tm4YFPicreAyr
• increased susceptibility to weight loss_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0010180NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal T-helper 17 cell differentiation_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0010221NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal regulatory T cell morphology_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004941IC57BL6C57BL6NTacNr4a2tm11PcnNr4a2tm11PcnGtROSA26Sortm9creESR1ArteGtROSA26SorGtROSA26Sortm9creESR1ArteGtROSA26SorNr4a2tm11Pcn
• abnormal T-helper 17 cell differentiation_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010221IC57BL6C57BL6NTacNr4a2tm11PcnNr4a2tm11PcnGtROSA26Sortm9creESR1ArteGtROSA26SorGtROSA26Sortm9creESR1ArteGtROSA26SorNr4a2tm11Pcn
• increased CD4-positive, alpha beta T cell number_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0008074NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• decreased regulatory T cell number_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0004974NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal regulatory T cell morphology_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0004941NSNr4a2tm11PcnNr4a2tm11PcnTgLckcre1Jtak0TgLckcre1JtakNr4a2tm11Pcn
• abnormal T-helper 1 cell differentiation_Nr4a2<tm1.1Pcn>/Nr4a2<tm1.1Pcn>,Gt(ROSA)26Sor<tm9(cre/ESR1)Arte>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008088IC57BL6C57BL6NTacNr4a2tm11PcnNr4a2tm11PcnGtROSA26Sortm9creESR1ArteGtROSA26SorGtROSA26Sortm9creESR1ArteGtROSA26SorNr4a2tm11Pcn

class

http://purl.org/net/cito/citesAsAuthority

• Nr4a1<tm1Pcn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5546594