Shichuan. Zhang, et.al., Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair., The Journal of cell biology, 2011, 193

http://rdf.ncbi.nlm.nih.gov/pubmed/21482716

Shichuan. Zhang, et.al., Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair., The Journal of cell biology, 2011, 193

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950416

class

http://purl.org/net/cito/citesAsAuthority

• Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4950416

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased mortality induced by ionizing radiation_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0003992I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• small lymphoid organs_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0000687I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• abnormal hematopoietic stem cell physiology_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0010763I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• thrombocytopenia_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0003179I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• increased cellular sensitivity to ultraviolet irradiation_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008410I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased hematopoietic stem cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0004810I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased CD8-positive, alpha-beta T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008079I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased mature B cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008211I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• postnatal lethality, incomplete penetrance_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0011086I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• arrested B cell differentiation_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0001802I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• abnormal immunoglobulin V(D)J recombination_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008755I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased granulocyte number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0000334I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• slow postnatal weight gain_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008489I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• pancytopenia_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0005152I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased double-positive T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0005092I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased leukocyte cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0000221I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• increased cellular sensitivity to alkylating agents_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008402I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• increased small intestinal crypt cell apoptosis_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008800I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• increased sensitivity to induced cell death_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008943I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• increased cellular sensitivity to ionizing radiation_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0004227I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• pallor_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0003717I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• premature death_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0002083I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• hyperpigmentation_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0001188I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased gamma-delta T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008347I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0005018I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased double-negative T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0005089I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased bone marrow cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0000333I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased lymphocyte cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0005016I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• abnormal DNA repair_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008058I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased macrophage cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0003884I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• hyperpigmentation_Prkdc<tm1.1Bpcc>/Prkdc<+>
  http://metadb.riken.jp/0001188I129C57BL6Prkdctm11BpccPrkdcPrkdctm11BpccPrkdc
• decreased CD4-positive, alpha beta T cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0008075I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc
• decreased erythrocyte cell number_Prkdc<tm1.1Bpcc>/Prkdc<tm1.1Bpcc>
  http://metadb.riken.jp/0002875I129C57BL6Prkdctm11BpccPrkdctm11BpccPrkdctm11Bpcc