Zhongyan. Zhang, et.al., The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells., Molecular biology of the cell, 2011, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/21551073

Zhongyan. Zhang, et.al., The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells., Molecular biology of the cell, 2011, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Opa1<tm1.2Hise>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5317789
• Opa1<tm1.1Hise>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5317788

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pancreatic beta cell proliferation_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011820I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• increased circulating glucose level_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005559I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• abnormal pancreatic beta cell morphology_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005217I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• decreased pancreatic beta cell number_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003339I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• abnormal mitochondrial crista morphology_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011635I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• small pancreatic islets_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0009172I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• decreased oxygen consumption_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005290I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• decreased insulin secretion_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003059I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• abnormal mitochondrion morphology_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0006035I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• decreased circulating insulin level_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002727I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• abnormal pancreatic beta cell physiology_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003562I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• abnormal respiratory electron transport chain_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0010955I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn
• embryonic lethality, complete penetrance_Opa1<tm1.2Hise>/Opa1<tm1.2Hise>
  http://metadb.riken.jp/0011092I129SSvEvC57BL6FVBNOpa1tm12HiseOpa1tm12HiseOpa1tm12Hise
• impaired glucose tolerance_Opa1<tm1.1Hise>/Opa1<tm1.2Hise>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005293I129SSvEvC57BL6DBASJLOpa1tm11HiseOpa1tm12HiseTgIns2cre25Mgn0Opa1tm12HiseOpa1tm11HiseTgIns2cre25Mgn

class

http://purl.org/net/cito/citesAsAuthority

• Opa1<tm1.2Hise>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5317789
• Opa1<tm1.1Hise>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5317788