Thanh T. Le, et.al., Temporal requirement for high SMN expression in SMA mice., Human molecular genetics, 2011, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/21672919

Thanh T. Le, et.al., Temporal requirement for high SMN expression in SMA mice., Human molecular genetics, 2011, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-SMN2,-luc)#bAhmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5318802
• Tg(tetO-SMN2,-luc)#aAhmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5286602
• Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5286599

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-SMN2,-luc)#bAhmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5318802
• Tg(tetO-SMN2,-luc)#aAhmb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5286602
• Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5286599

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal ear morphology_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0002102I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb
• hypoactivity_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0001402I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb
• postnatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0011085I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb
• decreased body size_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb
• premature death_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb
• abnormal intestine morphology_Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy>,Smn1<tm1Msd>/Smn1<+>,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
  http://metadb.riken.jp/0000477I129S1Sv129X1SvJC57BL6CBAFVBGtROSA26Sortm11rtTAEGFPNagyGtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgSMN2AhmbTgSMN2AhmbTgSMN2delta74299AhmbTgSMN2delta74299AhmbTgtetOSMN2lucaAhmb0GtROSA26Sortm11rtTAEGFPNagySmn1tm1MsdSmn1TgtetOSMN2lucaAhmbTgSMN2AhmbTgSMN2delta74299Ahmb