Carlo. Viscomi, et.al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis., Cell metabolism, 2011, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/21723506

Carlo. Viscomi, et.al., In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis., Cell metabolism, 2011, 14

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cox15<tm1.1Zev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292113
• Cox15<tm1.2Zev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292114

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal motor capabilities/coordination/movement_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0002066I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased sensitivity to xenobiotic induced morbidity/mortality_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0009766I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased mitochondrial fission_Tg(Ckm-Ppargc1a)31Brsp/0
  http://metadb.riken.jp/0006038C57BL6TgCkmPpargc1a31BrspJTgCkmPpargc1a31Brsp0TgCkmPpargc1a31Brsp
• abnormal aerobic respiration_Surf1<tm1Zev>/Surf1<tm1Zev>,Tg(Ckm-Ppargc1a)31Brsp/0
  http://metadb.riken.jp/0010957I129S7SvEvBrdC57BL6Surf1tm1ZevSurf1tm1ZevTgCkmPpargc1a31Brsp0TgCkmPpargc1a31BrspSurf1tm1Zev
• centrally nucleated skeletal muscle fibers_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0009404I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• myopathy_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0000751I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased variability of skeletal muscle fiber size_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0009403I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• abnormal mitochondrion morphology_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0006035I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased mitochondrial fission_Surf1<tm1Zev>/Surf1<tm1Zev>,Tg(Ckm-Ppargc1a)31Brsp/0
  http://metadb.riken.jp/0006038I129S7SvEvBrdC57BL6Surf1tm1ZevSurf1tm1ZevTgCkmPpargc1a31Brsp0TgCkmPpargc1a31BrspSurf1tm1Zev
• abnormal locomotor behavior_Sco2<tm1.1Easc>/Sco2<tm2.1Easc>
  http://metadb.riken.jp/0001392129X1SvJSco2tm11EascSco2tm21EascSco2tm11EascSco2tm21EascSco2tm21EascSco2tm11Easc
• abnormal aerobic respiration_Tg(Ckm-Ppargc1a)31Brsp/0
  http://metadb.riken.jp/0010957C57BL6TgCkmPpargc1a31BrspJTgCkmPpargc1a31Brsp0TgCkmPpargc1a31Brsp
• abnormal cellular respiration_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0010954I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased physiological sensitivity to xenobiotic_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0008873I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• increased mitochondrial fission_Cox15<tm1.1Zev>/Cox15<tm1.1Zev>,Tg(ACTA1-cre)79Jme/0
  http://metadb.riken.jp/0006038I129C57BL6C57BL6JSJLCox15tm11ZevCox15tm11ZevTgACTA1cre79Jme0Cox15tm11ZevTgACTA1cre79Jme
• embryonic lethality, complete penetrance_Cox15<tm1.2Zev>/Cox15<tm1.2Zev>
  http://metadb.riken.jp/0011092I129C57BL6Cox15tm12ZevCox15tm12ZevCox15tm12Zev

class

http://purl.org/net/cito/citesAsAuthority

• Cox15<tm1.1Zev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292113
• Cox15<tm1.2Zev>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5292114