Wim. de Lau, et.al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling., Nature, 2011, 476

http://rdf.ncbi.nlm.nih.gov/pubmed/21727895

Wim. de Lau, et.al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling., Nature, 2011, 476

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lgr4<tm1(cre/ERT2)Cle>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285689
• Lgr5<tm2.1Cle>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285688

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Lgr5<tm2.1Cle>/Lgr5<tm2.1Cle>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisLgr5tm21CleLgr5tm21CleTgCyp1a1cre1Dwi0Lgr5tm21CleLgr4tm11KnisTgCyp1a1cre1Dwi
• abnormal small intestinal crypt cell proliferation_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0010157I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisTgCyp1a1cre1Dwi0TgCyp1a1cre1DwiLgr4tm11Knis
• abnormal small intestinal crypt cell proliferation_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Lgr5<tm2.1Cle>/Lgr5<tm2.1Cle>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0010157I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisLgr5tm21CleLgr5tm21CleTgCyp1a1cre1Dwi0Lgr5tm21CleLgr4tm11KnisTgCyp1a1cre1Dwi
• decreased small intestinal villus size_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Lgr5<tm2.1Cle>/Lgr5<tm2.1Cle>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0008142I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisLgr5tm21CleLgr5tm21CleTgCyp1a1cre1Dwi0Lgr5tm21CleLgr4tm11KnisTgCyp1a1cre1Dwi
• decreased small intestinal villus size_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0008142I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisTgCyp1a1cre1Dwi0TgCyp1a1cre1DwiLgr4tm11Knis
• abnormal intestine physiology_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Lgr5<tm2.1Cle>/Lgr5<tm2.1Cle>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0010155I129P2OlaHsdC57BL6DBA2Lgr4tm11KnisLgr4tm11KnisLgr5tm21CleLgr5tm21CleTgVilcreERT223Syr0TgVilcreERT223SyrLgr5tm21CleLgr4tm11Knis
• premature death_Lgr4<tm1.1Knis>/Lgr4<tm1.1Knis>,Tg(Cyp1a1-cre)1Dwi/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBALgr4tm11KnisLgr4tm11KnisTgCyp1a1cre1Dwi0TgCyp1a1cre1DwiLgr4tm11Knis

class

http://purl.org/net/cito/citesAsAuthority

• Lgr4<tm1(cre/ERT2)Cle>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285689
• Lgr5<tm2.1Cle>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285688