Frédéric. Langevin, et.al., Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice., Nature, 2011, 475

http://rdf.ncbi.nlm.nih.gov/pubmed/21734703

Frédéric. Langevin, et.al., Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice., Nature, 2011, 475

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased bone marrow cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000333I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• kinked tail_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000585I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• enlarged spleen_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000691I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• exencephaly_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<+>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000914I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2Fancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2Aldh2tm1aEUCOMMWtsi
• exencephaly_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000914I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased body weight_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
他24件を見る
• weight loss_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001263I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• anophthalmia_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001293I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• anemia_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001577I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• impaired hematopoiesis_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001606I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• infertility_Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001924I129S4SvJaeFancd2tm1HouFancd2tm1HouFancd2tm1Hou
• decreased litter size_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0001935IC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsi
• increased T cell derived lymphoma incidence_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002024I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• premature death_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal eye morphology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<+>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002092I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2Fancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2Aldh2tm1aEUCOMMWtsi
• abnormal eye morphology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002092I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal bone marrow cell morphology/development_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002398I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal lymphopoiesis_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002401I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased hemoglobin content_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002874I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased erythrocyte cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• maternal effect_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<+>
  http://metadb.riken.jp/0003718I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2Fancd2Aldh2tm1aEUCOMMWtsiFancd2tm1Hou
• abnormal chest morphology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0004134I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased double-positive T cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0005091I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• lethargy_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0005202I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• embryonic lethality during organogenesis_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0006207I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased CD8-positive, alpha-beta T cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008078I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased sensitivity to induced cell death_Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008943I129S4SvJaeFancd2tm1HouFancd2tm1HouFancd2tm1Hou
• increased sensitivity to xenobiotic induced morbidity/mortality_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0009766I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased acute lymphoblastic leukemia incidence_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0010336I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased lymphoma incidence_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0012431I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi