Constantin. d'Ydewalle, et.al., HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease., Nature medicine, 2011, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/21785432

Constantin. d'Ydewalle, et.al., HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease., Nature medicine, 2011, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Thy1-HSPB1*P182L)#Lvdb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285201
• Tg(Thy1-HSPB1*S135F)#Lvdb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285200

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Thy1-HSPB1*P182L)#Lvdb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285201
• Tg(Thy1-HSPB1*S135F)#Lvdb
  http://metadb.riken.jp/db/mgi_rdf/MGI:5285200

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• limb grasping_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0001513IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal sensory neuron morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0000965IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal motor neuron morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0000937IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal motor neuron morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0000937IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal nervous system morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0003632IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal gait_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0001406IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• impaired coordination_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001405IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal action potential_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0005402IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal sensory neuron morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0000965IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• skeletal muscle fiber atrophy_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0009413IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• limb grasping_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001513IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal sciatic nerve morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0002651IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• decreased grip strength_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0010053IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal gastrocnemius morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0003082IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal nervous system morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0003632IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal sciatic nerve morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0002651IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• short stride length_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001407IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• impaired coordination_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0001405IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• skeletal muscle fiber atrophy_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0009413IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• short stride length_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0001407IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal axonal transport_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0004768IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal neuromuscular synapse morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001053IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal action potential_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0005402IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• decreased grip strength_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0010053IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• increased thermal nociceptive threshold_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001973IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal neuromuscular synapse morphology_Tg(Thy1-HSPB1*P182L)#Lvdb/0
  http://metadb.riken.jp/0001053IFVBNTgThy1HSPB1P182LLvdb0TgThy1HSPB1P182LLvdb
• abnormal gait_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0001406IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb
• abnormal gastrocnemius morphology_Tg(Thy1-HSPB1*S135F)#Lvdb/0
  http://metadb.riken.jp/0003082IFVBNTgThy1HSPB1S135FLvdb0TgThy1HSPB1S135FLvdb