Ralf. Ruediger, et.al., Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice., Molecular and cellular biology, 2011, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/21791616

Ralf. Ruediger, et.al., Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice., Molecular and cellular biology, 2011, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287375
• Ppp2r1a<tm3.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287370
• Ppp2r1a<tm1.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287252
• Ppp2r1a<tm1.2Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287362

class

http://purl.org/net/cito/citesAsAuthority

• Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287375
• Ppp2r1a<tm3.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287370
• Ppp2r1a<tm1.1Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287252
• Ppp2r1a<tm1.2Wltr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5287362

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• no abnormal phenotype detected_Ppp2r1a<tm2.1Wltr>/Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/0002169FVB129Ppp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm21Wltr
• increased lung adenoma incidence_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/0002048FVB129Ppp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm12Wltr
• ataxia_Ppp2r1a<tm1.1Wltr>/Ppp2r1a<tm1.2Wltr>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001393I129S1Sv129S4SvJaeSorC57BL6CBAFVBNCrlPpp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc0Ppp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc
• increased incidence of tumors by chemical induction_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<+>
  http://metadb.riken.jp/0004499FVB129S1Ppp2r1atm12WltrPpp2r1atm12WltrPpp2r1aPpp2r1atm12WltrPpp2r1a
• increased lung adenocarcinoma incidence_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/0002027FVB129Ppp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm12Wltr
• weight loss_Ppp2r1a<tm1.1Wltr>/Ppp2r1a<tm1.2Wltr>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001263I129S1Sv129S4SvJaeSorC57BL6CBAFVBNCrlPpp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc0Ppp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc
• increased lung tumor incidence_Ppp2r1a<tm2.1Wltr>/Ppp2r1a<+>
  http://metadb.riken.jp/0008014FVB129Ppp2r1atm21WltrPpp2r1atm21WltrPpp2r1aPpp2r1aPpp2r1atm21Wltr
• hunched posture_Ppp2r1a<tm1.1Wltr>/Ppp2r1a<tm1.2Wltr>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001505I129S1Sv129S4SvJaeSorC57BL6CBAFVBNCrlPpp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc0Ppp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc
• increased lung tumor incidence_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/0008014FVB129Ppp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm12Wltr
• increased lung tumor incidence_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<+>
  http://metadb.riken.jp/0008014FVB129S1Ppp2r1atm12WltrPpp2r1atm12WltrPpp2r1aPpp2r1atm12WltrPpp2r1a
• no abnormal phenotype detected_Ppp2r1a<tm3.1Wltr>/Ppp2r1a<tm3.1Wltr>
  http://metadb.riken.jp/0002169FVB129Ppp2r1atm31WltrPpp2r1atm31WltrPpp2r1atm31WltrPpp2r1atm31Wltr
• increased incidence of tumors by chemical induction_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<tm2.1Wltr>
  http://metadb.riken.jp/0004499FVB129Ppp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm12WltrPpp2r1atm21WltrPpp2r1atm21WltrPpp2r1atm12Wltr
• increased incidence of tumors by chemical induction_Ppp2r1a<tm2.1Wltr>/Ppp2r1a<+>
  http://metadb.riken.jp/0004499FVB129Ppp2r1atm21WltrPpp2r1atm21WltrPpp2r1aPpp2r1aPpp2r1atm21Wltr
• premature death_Ppp2r1a<tm1.1Wltr>/Ppp2r1a<tm1.2Wltr>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJaeSorC57BL6CBAFVBNCrlPpp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc0Ppp2r1atm11WltrPpp2r1atm12WltrTgCAGcreEsr15Amc
• embryonic lethality, complete penetrance_Ppp2r1a<tm1.2Wltr>/Ppp2r1a<tm1.2Wltr>
  http://metadb.riken.jp/0011092FVB129S1Ppp2r1atm12WltrPpp2r1atm12WltrPpp2r1atm12WltrPpp2r1atm12Wltr