Fan-Yan. Wei, et.al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21841312

Fan-Yan. Wei, et.al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cdkal1<tm1.1Tomik>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301441
• Cdkal1<tm1.2Tomik>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301443

class

http://purl.org/net/cito/citesAsAuthority

• Cdkal1<tm1.1Tomik>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301441
• Cdkal1<tm1.2Tomik>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301443

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal insulin secretion_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003564B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik
• abnormal pancreatic beta cell physiology_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003562B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik
• abnormal pancreatic islet morphology_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005215B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik
• increased circulating glucose level_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005559B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik
• no abnormal phenotype detected_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>
  http://metadb.riken.jp/0002169B6CgCdkal1tm11TomikCdkal1tm11TomikCdkal1tm11TomikCdkal1tm11Tomik
• abnormal cell physiology_Cdkal1<tm1.2Tomik>/Cdkal1<tm1.2Tomik>
  http://metadb.riken.jp/0005621B6CgCdkal1tm12TomikCdkal1tm12TomikCdkal1tm12TomikCdkal1tm12Tomik
• impaired glucose tolerance_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005293B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik
• decreased insulin secretion_Cdkal1<tm1.1Tomik>/Cdkal1<tm1.1Tomik>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003059B6CgCdkal1tm11TomikTgIns2cre25MgnCdkal1tm11TomikCdkal1tm11TomikTgIns2cre25Mgn0TgIns2cre25MgnCdkal1tm11Tomik