Arianna. Bertossi, et.al., Loss of Roquin induces early death and immune deregulation but not autoimmunity., The Journal of experimental medicine, 2011, 208

http://rdf.ncbi.nlm.nih.gov/pubmed/21844204

Arianna. Bertossi, et.al., Loss of Roquin induces early death and immune deregulation but not autoimmunity., The Journal of experimental medicine, 2011, 208

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301574
• Rc3h1<tm1.1Mass>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301575

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased CD8-positive, alpha-beta T cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008078IC57BL6DBA2NZBSJLRc3h1tm11MassRc3h1tm11MassTgCd4cre1Cwi0TgCd4cre1CwiRc3h1tm11Mass
• decreased IgA level_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0001807IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased eosinophil cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005011IC57BL6DBA2NZBSJLRc3h1tm11MassRc3h1tm11MassTgCd4cre1Cwi0TgCd4cre1CwiRc3h1tm11Mass
• increased spleen weight_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0004952IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal spleen B cell follicle morphology_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008470IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased IgG2b level_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008501IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased macrophage cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0005425IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal germinal center B cell physiology_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008192IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• decreased IgG3 level_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008498IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• neonatal lethality, complete penetrance_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0011087IC57BL6CBANZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• primary atelectasis_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0010819IC57BL6CBANZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• enlarged spleen_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0000691IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased eosinophil cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0005011IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased spleen weight_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0004952IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• decreased B cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0005017IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal thymus development_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0000704IC57BL6CBANZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• decreased body weight_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0001262IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• decreased bone marrow cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0000333IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal vertebral column morphology_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0004703IC57BL6CBANZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• curly tail_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0003051IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• increased macrophage cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005425IC57BL6DBA2NZBSJLRc3h1tm11MassRc3h1tm11MassTgCd4cre1Cwi0TgCd4cre1CwiRc3h1tm11Mass
• enlarged spleen_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0000691IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• increased regulatory T cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004973I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• enlarged spleen_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• increased B cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• curly tail_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0003051IC57BL6CBANZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• increased eosinophil cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005011I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• increased splenocyte number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0009338IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased spleen weight_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004952I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• decreased immature B cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008215IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal effector T cell morphology_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0002435IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• postnatal growth retardation_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0001732IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass
• abnormal B cell differentiation_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002144IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• spleen hyperplasia_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0000693IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal effector T cell morphology_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002435IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• increased regulatory T cell number_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0004973IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• decreased IgG1 level_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008495IC57BL6C57BL10CBACaNZBSJLRc3h1tm11MassRc3h1tm11MassTgVav1icreA2Kio0TgVav1icreA2KioRc3h1tm11Mass
• abnormal effector T cell morphology_Rc3h1<tm1.1Mass>/Rc3h1<tm1.1Mass>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002435I129P2OlaHsdC57BL6NZBSJLRc3h1tm11MassRc3h1tm11MassCd19tm1creCgnCd19Cd19tm1creCgnCd19Rc3h1tm11Mass
• preweaning lethality, incomplete penetrance_Rc3h1<tm1.2Mass>/Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/0011110IC57BL6CBACD1NZBSJLRc3h1tm12MassRc3h1tm12MassRc3h1tm12Mass

class

http://purl.org/net/cito/citesAsAuthority

• Rc3h1<tm1.2Mass>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301574
• Rc3h1<tm1.1Mass>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5301575