Matthew D. Hirschey, et.al., SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome., Molecular cell, 2011, 44

http://rdf.ncbi.nlm.nih.gov/pubmed/21856199

Matthew D. Hirschey, et.al., SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome., Molecular cell, 2011, 44

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating triglyceride level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0001552I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating interleukin-10 level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008593I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• abnormal cytokine level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008713I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• decreased oxygen consumption_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005290I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• decreased carbon dioxide production_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008964I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased total body fat amount_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0010024I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased liver triglyceride level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0009355I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating VLDL cholesterol level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005145I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating interleukin-12 level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008617I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• liver inflammation_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0001860I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• hyperglycemia_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0001559I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased liver cholesterol level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0010027I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating interferon-gamma level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008577I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased susceptibility to diet-induced obesity_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005658I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• abnormal glucose homeostasis_Scd1<tm1Ntam>/Scd1<tm1Ntam>,Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6Scd1tm1NtamScd1tm1NtamSirt3tm11FwaSirt3tm11FwaScd1tm1NtamSirt3tm11Fwa
• abnormal enzyme/coenzyme level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005319I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating interleukin-6 level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008596I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating cholesterol level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005178I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating tumor necrosis factor level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0008553I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• liver fibrosis_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0003333I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• insulin resistance_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0005331I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• increased circulating insulin level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0002079I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• abnormal lipid homeostasis_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0002118I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• hepatic steatosis_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0002628I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa
• abnormal triglyceride level_Scd1<tm1Ntam>/Scd1<tm1Ntam>,Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0000187I129S6SvEvTacC57BL6Scd1tm1NtamScd1tm1NtamSirt3tm11FwaSirt3tm11FwaScd1tm1NtamSirt3tm11Fwa
• increased circulating LDL cholesterol level_Sirt3<tm1.1Fwa>/Sirt3<tm1.1Fwa>
  http://metadb.riken.jp/0000182I129S6SvEvTacSirt3tm11FwaSirt3tm11FwaSirt3tm11Fwa