Anca. Alexandru, et.al., Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/21900558

Anca. Alexandru, et.al., Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294354
• Tg(Thy1-APP*)2.2Ingm
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294353
• Qpctl<m1Ingm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294355

class

http://purl.org/net/cito/citesAsAuthority

• Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294354
• Tg(Thy1-APP*)2.2Ingm
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294353
• Qpctl<m1Ingm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294355

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased vertical activity_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0002757IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• limb grasping_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0001513IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• hippocampus pyramidal cell degeneration_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0010014IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• decreased prepulse inhibition_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0009142IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• amyloid beta deposits_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0003329IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• slow postnatal weight gain_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0008489IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• abnormal excitatory postsynaptic potential_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0002912IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• abnormal behavior_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0004924IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• impaired coordination_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001405IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• abnormal hippocampus CA1 region morphology_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0008263IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• decreased food intake_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0011940IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• decreased body weight_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0001262IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• microgliosis_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0008918IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• decreased fluid intake_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0011942IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• reduced long term potentiation_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001473IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• amyloid beta deposits_Qpct<tm1.2Tbay>/Qpct<tm1.2Tbay>,Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0003329I129S2SvPasC57BL6JQpcttm12TbayQpcttm12TbayTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmQpcttm12Tbay
• abnormal posture_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001504IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• premature death_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0002083IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• decreased body weight_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001262IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• limb grasping_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001513IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• impaired righting response_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0001523IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• tremors_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0000745IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• astrocytosis_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0003354IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• microgliosis_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0008918IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• abnormal hippocampus morphology_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0000807IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• impaired righting response_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0001523IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• slow postnatal weight gain_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0008489IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• abnormal CNS synaptic transmission_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0002206IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• gliosis_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0002183IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• hippocampus pyramidal cell degeneration_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<+>,Tg(Thy1-APP*)2.2Ingm/0
  http://metadb.riken.jp/0010014IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1APP22Ingm0TgThy1APP22IngmTrib2TgThy1TrhAPP21IngmTrib2
• decreased hippocampus pyramidal cell number_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0009971IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• astrocytosis_Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0003354IC57BL6DBA1Trib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21Ingm
• amyloid beta deposits_Qpctl<m1Ingm>/Qpctl<m1Ingm>,Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>/Trib2<Tg(Thy1-Trh/APP*)2.1Ingm>
  http://metadb.riken.jp/0003329IC3HeBFeJQpctlm1IngmQpctlm1IngmTrib2TgThy1TrhAPP21IngmTrib2TgThy1TrhAPP21IngmQpctlm1IngmTrib2TgThy1TrhAPP21Ingm