Hao. Zhu, et.al., The Lin28/let-7 axis regulates glucose metabolism., Cell, 2011, 147

http://rdf.ncbi.nlm.nih.gov/pubmed/21962509

Hao. Zhu, et.al., The Lin28/let-7 axis regulates glucose metabolism., Cell, 2011, 147

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Lin28a<tm1.2Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5519953
• Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294613
• Lin28a<tm1Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294611
• Col1a1<tm2(tetO-LIN28B)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294612

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• improved glucose tolerance_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005292I129S4SvJaeC57BL6CD1Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOLIN28BGqda
• insulin resistance_Lin28a<tm1Gqda>/Lin28a<tm1Gqda>,Myf5<tm3(cre)Sor>/Myf5<+>
  http://metadb.riken.jp/0005331I129S4SvJaeC57BL6CD1Lin28atm1GqdaLin28atm1GqdaMyf5tm3creSorMyf5Myf5tm3creSorLin28atm1GqdaMyf5
• increased lean body mass_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0003960I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• improved glucose tolerance_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005292I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased insulin sensitivity_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002891I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• increased circulating insulin level_Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002079I129S4SvJaeC57BL6CD1Col1a1tm3tetOMirlet7gMir21GqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• decreased susceptibility to hepatic steatosis_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0002310I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased total body fat amount_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0010025I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased susceptibility to age related obesity_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0003213I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• impaired glucose tolerance_Lin28a<tm1Gqda>/Lin28a<tm1Gqda>,Myf5<tm3(cre)Sor>/Myf5<+>
  http://metadb.riken.jp/0005293I129S4SvJaeC57BL6CD1Lin28atm1GqdaLin28atm1GqdaMyf5tm3creSorMyf5Myf5tm3creSorLin28atm1GqdaMyf5
• decreased susceptibility to diet-induced obesity_Col1a1<tm1(tetO-Lin28a)Gqda>/Col1a1<+>
  http://metadb.riken.jp/0005659I129S4SvJaeC57BL6CD1Col1a1tm1tetOLin28aGqdaCol1a1Col1a1tm1tetOLin28aGqdaCol1a1
• decreased susceptibility to diet-induced obesity_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005659I129S4SvJaeC57BL6CD1Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOLIN28BGqda
• increased circulating glucose level_Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005559I129S4SvJaeC57BL6CD1Col1a1tm3tetOMirlet7gMir21GqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• hypoglycemia_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000189I129S4SvJaeC57BL6CD1Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOLIN28BGqda
• decreased body size_Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001265I129S4SvJaeC57BL6CD1Col1a1tm3tetOMirlet7gMir21GqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• postnatal growth retardation_Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001732I129S4SvJaeC57BL6CD1Col1a1tm3tetOMirlet7gMir21GqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased insulin sensitivity_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002891I129S4SvJaeC57BL6CD1Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOLIN28BGqda
• impaired glucose tolerance_Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005293I129S4SvJaeC57BL6CD1Col1a1tm3tetOMirlet7gMir21GqdaCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae

class

http://purl.org/net/cito/citesAsAuthority

• Lin28a<tm1.2Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5519953
• Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294613
• Lin28a<tm1Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294611
• Col1a1<tm2(tetO-LIN28B)Gqda>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294612