Fabian. Riediger, et.al., Prorenin receptor is essential for podocyte autophagy and survival., Journal of the American Society of Nephrology : JASN, 2011, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/22034640

Fabian. Riediger, et.al., Prorenin receptor is essential for podocyte autophagy and survival., Journal of the American Society of Nephrology : JASN, 2011, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Atp6ap2<tm1.1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776594

class

http://purl.org/net/cito/citesAsAuthority

• Atp6ap2<tm1.1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5776594

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating cholesterol level_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0005178IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• increased urine protein level_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0002962IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• podocyte foot process effacement_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0008140IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• abnormal autophagy_Atp6ap2<tm1.1Ics>/Y
  http://metadb.riken.jp/0008260IC57BL6C57BL6NAtp6ap2tm11IcsYAtp6ap2tm11Ics
• increased podocyte apoptosis_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0011282IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• abnormal renal tubule epithelium morphology_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0009640IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• postnatal lethality, complete penetrance_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0011085IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• increased circulating creatinine level_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0005553IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• increased blood urea nitrogen level_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0005565IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• abnormal autophagy_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0008260IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• dilated renal tubules_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0002705IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• abnormal cell cytoskeleton morphology_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0020378IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• abnormal podocyte morphology_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0005326IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• renal cast_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0011402IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• albuminuria_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0002871IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• absent proximal convoluted tubule brush border_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0011351IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics
• decreased circulating serum albumin level_Atp6ap2<tm1.1Ics>/Y,Tg(NPHS2-cre)295Lbh/0
  http://metadb.riken.jp/0005419IC57BL6C57BL6NSJLAtp6ap2tm11IcsYTgNPHS2cre295Lbh0TgNPHS2cre295LbhAtp6ap2tm11Ics