Masaki. Yoda, et.al., Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis., Blood, 2011, 118

http://rdf.ncbi.nlm.nih.gov/pubmed/22042698

Masaki. Yoda, et.al., Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis., Blood, 2011, 118

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Adam10<tm1.1Khr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305451

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Csf3r<tm1Link>/Csf3r<tm1Link>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S6SvEvTac129X1SvJC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrCsf3rtm1LinkCsf3rtm1LinkTgMx1cre1Cgn0Csf3rtm1LinkTgMx1cre1CgnAdam10tm11Khr
• decreased erythrocyte cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• abnormal T cell differentiation_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002145I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• no abnormal phenotype detected_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>
  http://metadb.riken.jp/0002169I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrAdam10tm11Khr
• increased spleen weight_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• increased leukocyte cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• decreased CD8-positive, alpha-beta T cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008079I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• increased neutrophil cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000219I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• increased spleen red pulp amount_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008476I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• thymus hypoplasia_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001823I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• abnormal granulocyte differentiation_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008111I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• decreased T cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005018I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• spleen hyperplasia_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Csf3r<tm1Link>/Csf3r<tm1Link>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000693I129S6SvEvTac129X1SvJC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrCsf3rtm1LinkCsf3rtm1LinkTgMx1cre1Cgn0Csf3rtm1LinkTgMx1cre1CgnAdam10tm11Khr
• abnormal granulocyte differentiation_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Csf3r<tm1Link>/Csf3r<tm1Link>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008111I129S6SvEvTac129X1SvJC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrCsf3rtm1LinkCsf3rtm1LinkTgMx1cre1Cgn0Csf3rtm1LinkTgMx1cre1CgnAdam10tm11Khr
• spleen hyperplasia_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000693I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• decreased hemoglobin content_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002874I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• myeloid hyperplasia_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• myeloid hyperplasia_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Csf3r<tm1Link>/Csf3r<tm1Link>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S6SvEvTac129X1SvJC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrCsf3rtm1LinkCsf3rtm1LinkTgMx1cre1Cgn0Csf3rtm1LinkTgMx1cre1CgnAdam10tm11Khr
• decreased double-positive T cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005092I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• enlarged spleen_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• abnormal spleen morphology_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• decreased hematocrit_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000208I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• abnormal bone marrow morphology_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002397I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• decreased CD4-positive, alpha beta T cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008075I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• small thymus_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000706I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• abnormal definitive hematopoiesis_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002123I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr
• increased hematopoietic stem cell number_Adam10<tm1.1Khr>/Adam10<tm1.1Khr>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809I129S6SvEvTacC57BL6C57BL6NAdam10tm11KhrAdam10tm11KhrTgMx1cre1Cgn0TgMx1cre1CgnAdam10tm11Khr

class

http://purl.org/net/cito/citesAsAuthority

• Adam10<tm1.1Khr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5305451