Mingjia. Tan, et.al., SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation., Developmental cell, 2011, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/22118770

Mingjia. Tan, et.al., SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation., Developmental cell, 2011, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell cycle_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0003077I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• abnormal vitelline vasculature morphology_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0003229I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• increased apoptosis_Nf1<tm1Par>/Nf1<tm1Par>,Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0006042I129C57BL6Nf1tm1ParNf1tm1ParRnf7GtXE423BygRnf7GtXE423BygNf1tm1ParRnf7GtXE423Byg
• embryonic growth retardation_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0003984I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• decreased angiogenesis_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0005602I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• increased embryonic tissue cell apoptosis_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0013504I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• abnormal visceral yolk sac blood island morphology_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0011204I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• abnormal cell differentiation_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0005076I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• pericardial edema_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0001787I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• abnormal angiogenesis_Nf1<tm1Par>/Nf1<tm1Par>,Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0000260I129C57BL6Nf1tm1ParNf1tm1ParRnf7GtXE423BygRnf7GtXE423BygNf1tm1ParRnf7GtXE423Byg
• decreased cell proliferation_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0000352I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• decreased cell proliferation_Nf1<tm1Par>/Nf1<tm1Par>,Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0000352I129C57BL6Nf1tm1ParNf1tm1ParRnf7GtXE423BygRnf7GtXE423BygNf1tm1ParRnf7GtXE423Byg
• increased spinal cord apoptosis_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0013182I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg
• embryonic growth retardation_Nf1<tm1Par>/Nf1<tm1Par>,Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0003984I129C57BL6Nf1tm1ParNf1tm1ParRnf7GtXE423BygRnf7GtXE423BygNf1tm1ParRnf7GtXE423Byg
• embryonic lethality during organogenesis, complete penetrance_Rnf7<Gt(XE423)Byg>/Rnf7<Gt(XE423)Byg>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6Rnf7GtXE423BygRnf7GtXE423BygRnf7GtXE423Byg