Caterina. Tiozzo, et.al., Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner., Endocrine-related cancer, 2012, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/22167068

Caterina. Tiozzo, et.al., Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner., Endocrine-related cancer, 2012, 19

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased thyroxine level_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005471B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• increased thyroid-stimulating hormone level_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005135B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• thyroid gland hyperplasia_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0003498B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• postnatal lethality, complete penetrance_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0011085B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• enlarged thyroid gland_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005355B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• enlarged thyroid gland_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005355I129S4SvJaeBALBcC57BL6Ptentm1HwuPtenTgNkx21cre2Sand0PtenPtentm1HwuTgNkx21cre2Sand
• abnormal thyroid gland morphology_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0000681B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• increased thyroid tumor incidence_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0010316B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtenTgNkx21cre2Sand0TgNkx21cre2SandPtenPtentm1Hwu
• abnormal thyroid follicle morphology_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0004696I129S4SvJaeBALBcC57BL6Ptentm1HwuPtenTgNkx21cre2Sand0PtenPtentm1HwuTgNkx21cre2Sand
• thyroid gland hyperplasia_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0003498I129S4SvJaeBALBcC57BL6Ptentm1HwuPtenTgNkx21cre2Sand0PtenPtentm1HwuTgNkx21cre2Sand
• abnormal thyroid follicle morphology_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0004696B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• thyroid gland hyperplasia_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0003498I129S4SvJaeBALBcC57BL6Ptentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• abnormal thyroid gland morphology_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0000681B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtenTgNkx21cre2Sand0TgNkx21cre2SandPtenPtentm1Hwu
• increased thyroid adenoma incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0003496B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• increased thyroxine level_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005470I129S4SvJaeBALBcC57BL6Ptentm1HwuPtenTgNkx21cre2Sand0PtenPtentm1HwuTgNkx21cre2Sand
• enlarged thyroid gland_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005355I129S4SvJaeBALBcC57BL6Ptentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu
• decreased thyroxine level_Pten<tm1Hwu>/Pten<+>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0005471B6CgPtentm1HwuTgNkx21cre2SandPtentm1HwuPtenTgNkx21cre2Sand0TgNkx21cre2SandPtenPtentm1Hwu
• abnormal thyroid gland morphology_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Nkx2-1-cre)2Sand/0
  http://metadb.riken.jp/0000681I129S4SvJaeBALBcC57BL6Ptentm1HwuPtentm1HwuTgNkx21cre2Sand0TgNkx21cre2SandPtentm1Hwu