Youngsoo. Lee, et.al., ATR maintains select progenitors during nervous system development., The EMBO journal, 2012, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/22266795

Youngsoo. Lee, et.al., ATR maintains select progenitors during nervous system development., The EMBO journal, 2012, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Topbp1<tm1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316209
• Atm<tm2Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316210

class

http://purl.org/net/cito/citesAsAuthority

• Topbp1<tm1Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316209
• Atm<tm2Pmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316210

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellum development_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000854I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal stratification in cerebral cortex_Atr<tm2Bal>/Atr<tm2Bal>,Emx1<tm1(cre)Krj>/Emx1<+>
  http://metadb.riken.jp/0000790I129S2SvPasC57BL6JAtrtm2BalAtrtm2BalEmx1tm1creKrjEmx1Emx1Atrtm2BalEmx1tm1creKrj
• ectopic Purkinje cell_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000885I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal embryonic/fetal subventricular zone morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004274I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• decreased cellular sensitivity to ionizing radiation_Atm<tm2Pmc>/Atm<tm2Pmc>,Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004228I129S2SvPasC57BL6SJLAtmtm2PmcAtmtm2PmcAtrtm2BalAtrtm2BalTgNescre1Kln0TgNescre1KlnAtrtm2BalAtmtm2Pmc
• decreased cellular sensitivity to ionizing radiation_Atm<tm2Pmc>/Atm<tm2Pmc>,Meox2<tm1(cre)Sor>/Meox2<+>
  http://metadb.riken.jp/0004228I129S4SvJaeSorC57BL6JAtmtm2PmcAtmtm2PmcMeox2tm1creSorMeox2Meox2tm1creSorMeox2Atmtm2Pmc
• decreased cerebellar granule cell number_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008924I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal cerebral cortex morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000788I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• hippocampus hypoplasia_Atr<tm2Bal>/Atr<tm2Bal>,Emx1<tm1(cre)Krj>/Emx1<+>
  http://metadb.riken.jp/0030004I129S2SvPasC57BL6JAtrtm2BalAtrtm2BalEmx1tm1creKrjEmx1Emx1Atrtm2BalEmx1tm1creKrj
• abnormal cerebral cortex morphology_Atr<tm2Bal>/Atr<tm2Bal>,Emx1<tm1(cre)Krj>/Emx1<+>
  http://metadb.riken.jp/0000788I129S2SvPasC57BL6JAtrtm2BalAtrtm2BalEmx1tm1creKrjEmx1Emx1Atrtm2BalEmx1tm1creKrj
• decreased body size_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001265I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal neuron proliferation_Atr<tm2Bal>/Atr<tm2Bal>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009967I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0Atrtm2BalTrp53tm1TyjTgNescre1Kln
• increased neuron apoptosis_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003203I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal corpus callosum morphology_Atr<tm2Bal>/Atr<tm2Bal>,Emx1<tm1(cre)Krj>/Emx1<+>
  http://metadb.riken.jp/0000780I129S2SvPasC57BL6JAtrtm2BalAtrtm2BalEmx1tm1creKrjEmx1Emx1Atrtm2BalEmx1tm1creKrj
• abnormal cerebral cortex morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Topbp1<tm1Pmc>/Topbp1<tm1Pmc>
  http://metadb.riken.jp/0000788I129S2SvPasC57BL6JEmx1tm1creKrjEmx1Topbp1tm1PmcTopbp1tm1PmcEmx1tm1creKrjEmx1Topbp1tm1Pmc
• abnormal neuron proliferation_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009967I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal nervous system morphology_Atr<tm2Bal>/Atr<tm2Bal>,Cdkn2a<tm2Brn>/Cdkn2a<tm2Brn>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003632I129P2OlaHsd129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalCdkn2atm2BrnCdkn2atm2BrnTgNescre1Kln0TgNescre1KlnAtrtm2BalCdkn2atm2Brn
• decreased cerebellar granule cell precursor proliferation_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0013551I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal rhombic lip morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0012525I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal nervous system morphology_Atr<tm2Bal>/Atr<tm2Bal>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003632I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0Atrtm2BalTrp53tm1TyjTgNescre1Kln
• abnormal neuron proliferation_Atr<tm2Bal>/Atr<tm2Bal>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0009967I129S2SvPasC57BL6CBAAtrtm2BalAtrtm2BalTgCAGcreEsr15Amc0Atrtm2BalTgCAGcreEsr15Amc
• abnormal corpus callosum morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000780I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal neuron apoptosis_Atr<tm2Bal>/Atr<tm2Bal>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003202I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTrp53tm1TyjTrp53tm1TyjTgNescre1Kln0Atrtm2BalTrp53tm1TyjTgNescre1Kln
• postnatal growth retardation_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001732I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• postnatal lethality, complete penetrance_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011085I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal olfactory bulb granule cell layer morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009949I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal neuron apoptosis_Atm<tm2Pmc>/Atm<tm2Pmc>,Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003202I129S2SvPasC57BL6SJLAtmtm2PmcAtmtm2PmcAtrtm2BalAtrtm2BalTgNescre1Kln0TgNescre1KlnAtrtm2BalAtmtm2Pmc
• abnormal cerebellar granule layer morphology_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000886I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln
• abnormal nervous system morphology_Atm<tm2Pmc>/Atm<tm2Pmc>,Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003632I129S2SvPasC57BL6SJLAtmtm2PmcAtmtm2PmcAtrtm2BalAtrtm2BalTgNescre1Kln0TgNescre1KlnAtrtm2BalAtmtm2Pmc
• decreased brain size_Atr<tm2Bal>/Atr<tm2Bal>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774I129S2SvPasC57BL6SJLAtrtm2BalAtrtm2BalTgNescre1Kln0Atrtm2BalTgNescre1Kln