Sébastien. Malinge, et.al., Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome., The Journal of clinical investigation, 2012, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/22354171

Sébastien. Malinge, et.al., Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome., The Journal of clinical investigation, 2012, 122

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• extramedullary hematopoiesis_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0000240I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• thrombocytosis_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0005505I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• increased megakaryocyte cell number_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0008254I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr
• abnormal common myeloid progenitor cell morphology_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0006410I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr
• thrombocytosis_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0005505I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr
• enlarged spleen_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0000691I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• abnormal bone marrow cell morphology/development_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0002398I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• anemia_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0001577I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• increased megakaryocyte cell number_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0008254I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• abnormal megakaryocyte progenitor cell morphology_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0002413I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• abnormal bone marrow cell number_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0000172I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• abnormal megakaryocyte progenitor cell morphology_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0002413I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr
• increased monocyte cell number_Dp(16Cbr1-Fam3b)1Rhr/0,Gata1<tm8.2Sho>/Y
  http://metadb.riken.jp/0000220I129S1Sv129S6SvEvTacDp16Cbr1Fam3b1Rhr0Gata1tm82ShoYGata1tm82ShoDp16Cbr1Fam3b1Rhr
• decreased erythrocyte cell number_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0002875I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr
• increased hematopoietic stem cell number_Dp(16Cbr1-Fam3b)1Rhr/0
  http://metadb.riken.jp/0004809I129S6SvEvTacDp16Cbr1Fam3b1Rhr0Dp16Cbr1Fam3b1Rhr