Seo-Hee. Cho, et.al., Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis., Human molecular genetics, 2012, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/22398208

Seo-Hee. Cho, et.al., Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis., Human molecular genetics, 2012, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• microgliosis_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008918NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• absent photoreceptor outer segment_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008585NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• short photoreceptor inner segment_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008582NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• thin retinal ganglion layer_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008507NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retinal outer nuclear layer morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0003731NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• absent photoreceptor inner segment_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008583NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retinal photoreceptor morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001004NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• microphthalmia_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001297NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retina outer limiting membrane morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0010236NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• retinal degeneration_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001326NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• thin retinal outer nuclear layer_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008515NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• retinal photoreceptor degeneration_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008450NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retina morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001325NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal photoreceptor outer segment morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0003729NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• astrocytosis_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0003354NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal eye electrophysiology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0005551NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal cell proliferation_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0000350NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retina morphology_Mpp5<tm1Caw>/Mpp5<+>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001325NSMpp5tm1CawMpp5Tgrx3icre1Mjam0Tgrx3icre1MjamMpp5tm1CawMpp5
• decreased cell proliferation_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0000352NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• increased retinal apoptosis_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0030005NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal rod electrophysiology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0004021NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retinal rod cell morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0001005NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• short photoreceptor outer segment_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008587NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• retinal ganglion cell degeneration_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008067NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• retinal outer nuclear layer degeneration_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008518NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retinal photoreceptor layer morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0003728NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• abnormal retinal inner plexiform layer morphology_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0003734NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• thin retinal inner plexiform layer_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008513NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• disorganized retinal ganglion layer_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008509NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam
• disorganized retinal outer nuclear layer_Mpp5<tm1Caw>/Mpp5<tm1Caw>,Tg(rx3-icre)1Mjam/0
  http://metadb.riken.jp/0008516NSMpp5tm1CawMpp5tm1CawTgrx3icre1Mjam0Mpp5tm1CawTgrx3icre1Mjam