Rocky G. Gogliotti, et.al., Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22423102

Rocky G. Gogliotti, et.al., Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 32

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smn1<tm1.1Cdid>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836034

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001262I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• abnormal innervation_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0002184I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• abnormal motor capabilities/coordination/movement_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0002066I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• lethargy_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0005202I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• decreased body weight_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001262I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• impaired righting response_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001523I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• prolonged QT interval_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0003233I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• decreased single cell response threshold_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0003466I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• prolonged PR interval_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0003896I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• motor neuron degeneration_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0000938I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• abnormal innervation pattern to muscle_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001052I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• abnormal spinal cord morphology_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0000955I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• decreased heart rate_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0005333I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• irregular heartbeat_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001636I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• decreased motor neuron number_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0000939I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• decreased heart rate_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0005333I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• prolonged PR interval_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0003896I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• prolonged QT interval_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0003233I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• altered righting response_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0002862I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• no abnormal phenotype detected_Smn1<tm1Cdid>/Smn1<tm1.1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0002169I129C57BL6FVBSmn1tm1CdidSmn1tm11CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1CdidSmn1tm11Cdid
• prolonged QRS complex duration_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0010392I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• paralysis_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0000753I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• abnormal neuromuscular synapse morphology_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001053I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• decreased motor neuron number_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0000939I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• abnormal motor coordination/ balance_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0001516I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid
• postnatal lethality, complete penetrance_Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0011085I129C57BL6FVBSmn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Grm7TgSMN289AhmbSmn1tm1Cdid
• postnatal lethality, complete penetrance_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Smn1<tm1Cdid>/Smn1<tm1Cdid>,Grm7<Tg(SMN2)89Ahmb>/0
  http://metadb.riken.jp/0011085I129129S1SvC57BL6FVBMnx1tm4creTmjMnx1Smn1tm1CdidSmn1tm1CdidGrm7TgSMN289Ahmb0Mnx1tm4creTmjGrm7TgSMN289AhmbMnx1Smn1tm1Cdid

class

http://purl.org/net/cito/citesAsAuthority

• Smn1<tm1.1Cdid>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4836034