Pedro M. Quirós, et.al., Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice., The EMBO journal, 2012, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/22433842

Pedro M. Quirós, et.al., Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice., The EMBO journal, 2012, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Oma1<tm1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426689

class

http://purl.org/net/cito/citesAsAuthority

• Oma1<tm1Otin>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5426689

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased body weight_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0001260I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased circulating triglyceride level_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0001552I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal glucose homeostasis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• granulomatous inflammation_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002500I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• hepatic steatosis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased circulating insulin level_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
他23件を見る
• increased insulin sensitivity_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002891I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased circulating alanine transaminase level_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0002941I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal gas homeostasis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0003948I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased oxygen consumption_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005290I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• impaired glucose tolerance_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased circulating aspartate transaminase level_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005343I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased body temperature_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005534I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal cell physiology_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005621I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased susceptibility to diet-induced obesity_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005658I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased circulating leptin level_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0005669I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal mitochondrion morphology_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0006035I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased cellular sensitivity to alkylating agents_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0008403I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal mesenteric fat pad morphology_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0008903I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased carbon dioxide production_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0008964I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased white fat cell size_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0009118I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased gonadal fat pad weight_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0009285I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal blood homeostasis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0009642I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal circadian temperature homeostasis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0011020I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• increased mitochondria size_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0011630I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased mitochondrial DNA content_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0011639I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• abnormal brown adipose tissue thermogenesis_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0011699I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased fatty acid beta-oxidation_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0014174I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin
• decreased basal metabolism_Oma1<tm1Otin>/Oma1<tm1Otin>
  http://metadb.riken.jp/0020234I129S6SvEvTacC57BL6C57BL6NCrOma1tm1OtinOma1tm1OtinOma1tm1Otin