Chad E. Grueter, et.al., A cardiac microRNA governs systemic energy homeostasis by regulation of MED13., Cell, 2012, 149

http://rdf.ncbi.nlm.nih.gov/pubmed/22541436

Chad E. Grueter, et.al., A cardiac microRNA governs systemic energy homeostasis by regulation of MED13., Cell, 2012, 149

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Myh6-Med13)1Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431514
• Med13<tm1Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431516

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Myh6-Med13)1Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431514
• Med13<tm1Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5431516

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased interscapular fat pad weight_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0009295B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• abnormal circulating cholesterol level_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0000180B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• decreased total body fat amount_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0010025B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• increased brown adipose tissue amount_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000005I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased liver weight_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002981I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• abnormal triglyceride level_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0000187B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• improved glucose tolerance_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0005292B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• increased white fat cell size_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0009118I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• improved glucose tolerance_Lep<ob>/Lep<ob>,Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0005292IC57BL6LepobLepobTgMyh6Med131Eno0TgMyh6Med131EnoLepob
• decreased body weight_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0001262B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• decreased white adipose tissue amount_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0001783B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• increased circulating insulin level_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002079I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased circulating cholesterol level_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005178I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• abnormal interscapular fat pad morphology_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0006320B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• increased circulating leptin level_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005669I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased oxygen consumption_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0005289B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• decreased body weight_Lep<ob>/Lep<ob>,Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0001262IC57BL6LepobLepobTgMyh6Med131Eno0TgMyh6Med131EnoLepob
• impaired glucose tolerance_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005293I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased abdominal adipose tissue amount_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0020411I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased body weight_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001260I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased total body fat amount_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010024I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased lean body mass_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003960I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased carbon dioxide production_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0008963B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno
• increased liver triglyceride level_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0009355I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased circulating triglyceride level_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001552I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• increased susceptibility to diet-induced obesity_Med13<tm1Eno>/Med13<tm1Eno>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005658I129C57BL6FVBNMed13tm1EnoMed13tm1EnoTgMyh6cre2182Mds0Med13tm1EnoTgMyh6cre2182Mds
• decreased susceptibility to diet-induced obesity_Tg(Myh6-Med13)1Eno/0
  http://metadb.riken.jp/0005659B6CgTgMyh6Med131EnoTgMyh6Med131Eno0TgMyh6Med131Eno