Sheri L. Bonar, et.al., Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice., PloS one, 2012, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/22558291

Sheri L. Bonar, et.al., Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice., PloS one, 2012, 7

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nlrp3<tm3Hhf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5308094
• Nlrp3<tm3.1Hhf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5517707

class

http://purl.org/net/cito/citesAsAuthority

• Nlrp3<tm3Hhf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5308094
• Nlrp3<tm3.1Hhf>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5517707

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0001262I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-6 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008596I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased circulating interleukin-5 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008627I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• anemia_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0001577I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal bone marrow cavity morphology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000065I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-1 beta level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008641I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal long bone epiphysis morphology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000131I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased interleukin-1 beta secretion_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008657I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal trabecular bone morphology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000130I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased bone mineral density_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000063I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-3 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008623I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased circulating interleukin-12b level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008648I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased granulocyte number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000322I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• postnatal growth retardation_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0001732I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased monocyte cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000220I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• brain inflammation_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0001847I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased lymphocyte cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0005016I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal chondrocyte physiology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0009780I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating tumor necrosis factor level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008553I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased trabecular bone mass_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0010873I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased erythrocyte cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0002875I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased interferon-gamma secretion_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008566I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal circulating chemokine level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0010209I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased trabecular bone thickness_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0009346I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased compact bone area_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0010968I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• postnatal lethality, complete penetrance_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0011085I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal skeleton development_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0002113I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• joint inflammation_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0002933I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• osteomyelitis_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0005190I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• disorganized long bone epiphyseal plate_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0006397I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal femur morphology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000559I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased bone trabecula number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0010869I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• thrombocytosis_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0005505I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-9 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008629I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased neutrophil cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000219I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased inflammatory response_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0001846I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-18 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008635I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased bone mass_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0004016I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased lymphocyte cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0005013I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased osteoclast cell number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0004984I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased bone resorption_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0004992I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal long bone hypertrophic chondrocyte zone_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000165I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-13 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008608I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased width of hypertrophic chondrocyte zone_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0003409I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal osteoclast differentiation_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008396I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased compact bone thickness_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000135I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• increased circulating interleukin-4 level_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0008602I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• abnormal bone marrow cell physiology_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0009278I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased chondrocyte number_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000167I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3
• decreased cell proliferation_Nlrp3<tm3.1Hhf>/Nlrp3<+>
  http://metadb.riken.jp/0000352I129Nlrp3tm31HhfNlrp3Nlrp3tm31HhfNlrp3