Angela C. Johnson, et.al., Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease., European journal of immunology, 2012, 42

http://rdf.ncbi.nlm.nih.gov/pubmed/22585710

Angela C. Johnson, et.al., Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease., European journal of immunology, 2012, 42

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0000691B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• spleen hyperplasia_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0000693B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased IgG level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0001805B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• decreased IgG level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0001805B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased IgG level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002493B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased IgM level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0002494B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
他41件を見る
• increased IgM level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0002494B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased autoantibody level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0003725B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased autoantibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0003725B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased autoantibody level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0003726B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased anti-double stranded DNA antibody level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004762B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased anti-double stranded DNA antibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004762B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased anti-nuclear antigen antibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004794B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased anti-histone antibody level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004796B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased anti-histone antibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004796B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased anti-chromatin antibody level_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004829B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased anti-chromatin antibody level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004829B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased spleen weight_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0004952B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0005014B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0005014B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased T cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0005018B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• decreased T cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0005018B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• abnormal renal glomerulus morphology_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0005325B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• abnormal renal glomerulus morphology_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0005325B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• abnormal renal glomerulus morphology_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0005325B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• decreased plasma cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008098B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• lymph node hyperplasia_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008102B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased follicular B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008173B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased marginal zone B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008181B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased marginal zone B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008181B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased marginal zone B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008181B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• abnormal transitional stage B cell morphology_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008188B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• abnormal transitional stage B cell morphology_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008188B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• abnormal transitional stage B cell morphology_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008188B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased mature B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008210B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased immature B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0008214B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased immature B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008214B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• increased immature B cell number_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008214B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased IgG1 level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008499B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• enlarged cervical lymph nodes_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008542B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased IgG2c level_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0008896B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• increased transitional stage T2 B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0009925B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• increased transitional stage T3 B cell number_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>
  http://metadb.riken.jp/0010229B6129P2Tcrbtm1MomTcrdtm1MomJTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTcrbtm1MomTcrdtm1Mom
• abnormal glomerular capillary morphology_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0011320B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• abnormal glomerular capillary morphology_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0011320B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix
• mesangial cell hyperplasia_Tcrb<tm1Mom>/Tcrb<tm1Mom>,Tcrd<tm1Mom>/Tcrd<tm1Mom>,Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0011427B6129Tcrbtm1MomTraf3ip2tm11LixTcrdtm1MomTcrbtm1MomTcrbtm1MomTcrdtm1MomTcrdtm1MomTraf3ip2tm11LixTraf3ip2tm11LixTcrbtm1MomTcrdtm1MomTraf3ip2tm11Lix
• mesangial cell hyperplasia_Traf3ip2<tm1.1Lix>/Traf3ip2<tm1.1Lix>
  http://metadb.riken.jp/0011427B6129Traf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11LixTraf3ip2tm11Lix