L. van Buerck, et.al., Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants., Molecular and cellular endocrinology, 2012, 362

http://rdf.ncbi.nlm.nih.gov/pubmed/22698525

L. van Buerck, et.al., Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants., Molecular and cellular endocrinology, 2012, 362

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pancreatic beta cell mass_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0009114C3HeBFeJGckGls006GckGls006GckGckGckGls006
• small pancreatic islets_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0009172C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• increased circulating glucose level_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0005559C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• decreased body weight_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0001262C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• small pancreatic islets_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0009172C3HeBFeJGckGls006GckGls006GckGckGckGls006
• decreased pancreatic beta cell mass_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0009114C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• increased circulating glucose level_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0005559C3HeBFeJGckGls006GckGls006GckGckGckGls006
• decreased glucokinase activity_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0011606C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• decreased circulating insulin level_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0002727C3HeBFeJGckGls006GckGls006GckGckGckGls006
• impaired glucose tolerance_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0005293C3HeBFeJGckGls006GckGls006GckGckGckGls006
• hyperglycemia_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0001559C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• decreased insulin secretion_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0003059C3HeBFeJGckGls006GckGls006GckGckGckGls006
• hyperglycemia_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0001559C3HeBFeJGckGls006GckGls006GckGckGckGls006
• decreased glucokinase activity_Gck<Gls006>/Gck<+>
  http://metadb.riken.jp/0011606C3HeBFeJGckGls006GckGls006GckGckGckGls006
• abnormal pancreatic islet morphology_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0005215C3HeBFeJGckGls006GckGls006GckGls006GckGls006
• abnormal pancreatic beta cell morphology_Gck<Gls006>/Gck<Gls006>
  http://metadb.riken.jp/0005217C3HeBFeJGckGls006GckGls006GckGls006GckGls006