Masaya. Baba, et.al., The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development., Blood, 2012, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/22709692

Masaya. Baba, et.al., The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development., Blood, 2012, 120

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fnip1<tm1.1Baba>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445115
• Fnip1<tm1.2Baba>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445116

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased pre-B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008209I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• absent B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008071I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygTgIghelMD44Ccg0Fnip1GtRRM154BygTgIghelMD44Ccg
• decreased transitional stage B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008190I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• decreased B-1 B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0004978IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• decreased mature B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008211IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• absent B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008071IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• arrested B cell differentiation_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0001802I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• increased pro-B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008186IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• absent B-2 B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0008205I129P2OlaHsdC57BL6FVBNSJLFnip1tm12BabaFnip1tm12BabaIghtm2CgnIghtm2CgnFnip1tm12BabaIghtm2Cgn
• decreased B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0005017I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• increased B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0005014IC57BL6FVBNSJLFnip1tm12BabaFnip1tm12BabaTgBCL222Wehi0TgBCL222WehiFnip1tm12Baba
• decreased B-1 B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004978IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaTgIghelMD44Ccg0Fnip1tm12BabaTgIghelMD44Ccg
• decreased B-1 B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0004978I129P2OlaHsdC57BL6FVBNSJLFnip1tm12BabaFnip1tm12BabaIghtm2CgnIghtm2CgnFnip1tm12BabaIghtm2Cgn
• absent B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0008071I129P2OlaHsdC57BL6FVBNSJLFnip1tm12BabaFnip1tm12BabaIghtm2CgnIghtm2CgnFnip1tm12BabaIghtm2Cgn
• small spleen_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0000692IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• increased immature B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008214I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygTgIghelMD44Ccg0Fnip1GtRRM154BygTgIghelMD44Ccg
• absent B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008071I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• absent B-2 B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008205IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• arrested B cell differentiation_Flcn<tm1Baba>/Flcn<tm1.1Lss>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001802I129S1Sv129X1SvJFlcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe0Flcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe
• decreased B-1 B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004978I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygTgIghelMD44Ccg0Fnip1GtRRM154BygTgIghelMD44Ccg
• absent B-2 B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008205I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• decreased B-1 B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0004978I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• increased B cell apoptosis_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008782I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• absent B-2 B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008205I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygTgIghelMD44Ccg0Fnip1GtRRM154BygTgIghelMD44Ccg
• increased B cell apoptosis_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008782IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• decreased mature B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• decreased B cell number_Flcn<tm1Baba>/Flcn<tm1.1Lss>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0005017I129S1Sv129X1SvJFlcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe0Flcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe
• decreased B-1 B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0004978I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygIghtm2CgnIghtm2CgnIghtm2CgnFnip1GtRRM154Byg
• arrested B cell differentiation_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0001802IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• increased immature B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008214IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaTgIghelMD44Ccg0Fnip1tm12BabaTgIghelMD44Ccg
• increased B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Tg(BCL2)22Wehi/0
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygTgBCL222Wehi0Fnip1GtRRM154BygTgBCL222Wehi
• absent B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008071IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaTgIghelMD44Ccg0Fnip1tm12BabaTgIghelMD44Ccg
• absent B-2 B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0008205I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygIghtm2CgnIghtm2CgnIghtm2CgnFnip1GtRRM154Byg
• kidney failure_Flcn<tm1Baba>/Flcn<tm1.1Lss>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0003606I129S1Sv129X1SvJFlcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe0Flcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe
• kidney cysts_Flcn<tm1Baba>/Flcn<tm1.1Lss>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0003675I129S1Sv129X1SvJFlcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe0Flcntm1BabaFlcntm11LssTgCAGcreEsr11Lbe
• decreased pre-B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008209IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• absent B-2 B cells_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008205IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaTgIghelMD44Ccg0Fnip1tm12BabaTgIghelMD44Ccg
• increased pro-B cell number_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0008186I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• small spleen_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>
  http://metadb.riken.jp/0000692I129P2OlaHsdC57BL6JFnip1GtRRM154BygFnip1GtRRM154BygFnip1GtRRM154Byg
• absent B cells_Fnip1<Gt(RRM154)Byg>/Fnip1<Gt(RRM154)Byg>,Igh<tm2Cgn>/Igh<tm2Cgn>
  http://metadb.riken.jp/0008071I129P2OlaHsdC57BL6FVBNSJLFnip1GtRRM154BygFnip1GtRRM154BygIghtm2CgnIghtm2CgnIghtm2CgnFnip1GtRRM154Byg
• decreased B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0005017IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba
• decreased transitional stage B cell number_Fnip1<tm1.2Baba>/Fnip1<tm1.2Baba>
  http://metadb.riken.jp/0008190IC57BL6C57BL6JFVBNSJLFnip1tm12BabaFnip1tm12BabaFnip1tm12Baba

class

http://purl.org/net/cito/citesAsAuthority

• Fnip1<tm1.1Baba>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445115
• Fnip1<tm1.2Baba>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445116