Sebastian. Königsberger, et.al., Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state., The EMBO journal, 2012, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/22728826

Sebastian. Königsberger, et.al., Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state., The EMBO journal, 2012, 31

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5442724

class

http://purl.org/net/cito/citesAsAuthority

• Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5442724

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased CD4-positive, alpha beta T cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008074B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased B cell apoptosis_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008782B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased circulating creatinine level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0005554B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased IgG2b level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008497B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased transitional stage B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008190B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased CD8-positive, alpha-beta T cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008078B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0005017B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased CD8-positive, alpha-beta memory T cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0010838B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• expanded mesangial matrix_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0011353B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased IgG2a level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008496B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased urine protein level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002962B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased transitional stage T2 B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0009926B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased DN3 thymocyte number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0010133B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• abnormal renal glomerular capsule morphology_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002828B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased blood urea nitrogen level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0005566B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased anti-insulin autoantibody level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002869B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased IgG1 level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008495B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• abnormal renal glomerulus basement membrane morphology_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0011348B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• mesangial cell hyperplasia_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0011427B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• abnormal neutrophil physiology_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002463B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased DN1 thymic pro-T cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0010130B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased IgM level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002494B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• glomerulonephritis_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002743B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• arrested B cell differentiation_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0001802B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased CD4-positive, alpha-beta memory T cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0010835B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased bone marrow cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0000333B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• increased circulating glucose level_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0005559B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• abnormal B cell physiology_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0002459B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased mature B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008211B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased marginal zone B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0008182B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr
• decreased transitional stage T1 B cell number_Syk<tm2.1(ZAP70)Fkfr>/Syk<tm2.1(ZAP70)Fkfr>
  http://metadb.riken.jp/0009923B6129Syktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70FkfrSyktm21ZAP70Fkfr