Xian. Lin, et.al., Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22764233

Xian. Lin, et.al., Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 32

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pitx3<tm1.1Cai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5432011

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• microgliosis_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008918I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal neurite morphology_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008415I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• neuron degeneration_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003224I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal autophagy_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008260I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• decreased dopamine level_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0005643I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• impaired coordination_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0001405I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal synaptic dopamine release_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0010149I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal gait_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0001406I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• decreased vertical activity_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0002757I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• slow postnatal weight gain_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008489I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• short stride length_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0001407I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal neuron physiology_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0004811I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• abnormal dopaminergic neuron morphology_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003243I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• alpha-synuclein inclusion body_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0008493I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• hypoactivity_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0001402I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• loss of dopaminergic neurons_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003244I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai
• astrocytosis_Pitx3<tm1.1Cai>/Pitx3<+>,Tg(tetO-SNCA*A53T)E2Cai/0
  http://metadb.riken.jp/0003354I129C57BL6JFVBNPitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai0Pitx3tm11CaiPitx3TgtetOSNCAA53TE2Cai

class

http://purl.org/net/cito/citesAsAuthority

• Pitx3<tm1.1Cai>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5432011