Sheng. Xiao, et.al., Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

http://rdf.ncbi.nlm.nih.gov/pubmed/22773818

Sheng. Xiao, et.al., Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Havcr1<tm1Kuch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437711

class

http://purl.org/net/cito/citesAsAuthority

• Havcr1<tm1Kuch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437711

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased autoantibody level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0003725B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased IgG2a level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008500B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased CD4-positive, alpha beta T cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008074B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased T cell number_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005015B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased anti-double stranded DNA antibody level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0004762B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased IgG1 level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008499B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased double-negative T cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005090B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased CD8-positive, alpha-beta T cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008078B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased B cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005014B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• abnormal CD4-positive, alpha-beta T cell physiology_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005463B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• enlarged lymph nodes_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0000702B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased double-negative T cell number_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005090B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased IgG3 level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008502B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased T cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0005015B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased anti-double stranded DNA antibody level_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0004762B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased CD4-positive, alpha beta T cell number_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008074B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• autoimmune response_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0001844B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• abnormal dendritic cell physiology_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0002376B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased CD8-positive, alpha-beta T cell number_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008078B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased susceptibility to systemic lupus erythematosus_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0004801B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• abnormal immunoglobulin level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0002490B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased IgG2b level_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0008501B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• enlarged spleen_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0000691B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• increased activated T cell number_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0001829B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• abnormal T cell differentiation_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0002145B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• enlarged spleen_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0000691B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch
• increased activated T cell number_Fas<lpr>/Fas<lpr>,Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0001829B6CgHavcr1tm1KuchFaslprFaslprFaslprHavcr1tm1KuchHavcr1tm1KuchFaslprHavcr1tm1Kuch
• abnormal B cell physiology_Havcr1<tm1Kuch>/Havcr1<tm1Kuch>
  http://metadb.riken.jp/0002459B6CgHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1KuchHavcr1tm1Kuch