Francisca. Diaz, et.al., A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions., Human molecular genetics, 2012, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/22914734

Francisca. Diaz, et.al., A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions., Human molecular genetics, 2012, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neuron degeneration_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003224I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal piriform cortex morphology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0010009I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• neuron degeneration_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003224I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal somatosensory cortex morphology_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0000859I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal nervous system physiology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003633I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• hippocampal neuron degeneration_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0000811I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• neurodegeneration_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002229I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• neurodegeneration_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002229I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• hypoactivity_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0001402I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal locomotor activation_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003313I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• premature death_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002083I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal enzyme/coenzyme activity_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0005584I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• increased mitochondrial fission_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0006038I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal mitochondrial physiology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0006036I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal enzyme/coenzyme activity_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0005584I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• premature death_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002083I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal piriform cortex morphology_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0010009I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• decreased brain weight_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002175I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• impaired coordination_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0001405I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal glial cell physiology_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003690I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• abnormal cerebral cortex morphology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0000788I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal mitochondrial physiology_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0006036I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• impaired coordination_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0001405I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• hippocampal neuron degeneration_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0000811I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• decreased brain weight_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0002175I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• decreased body weight_Uqcrfs1<tm1Ctm>/Uqcrfs1<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0001262I129C57BL6C57BL6JCBAUqcrfs1tm1CtmUqcrfs1tm1CtmTgCamk2acreSzi0TgCamk2acreSziUqcrfs1tm1Ctm
• decreased body weight_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0001262I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal glial cell physiology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0003690I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm
• abnormal cingulate gyrus morphology_Cox10<tm1Ctm>/Cox10<tm1Ctm>,Tg(Camk2a-cre)#Szi/0
  http://metadb.riken.jp/0004167I129X1SvJC57BL6C57BL6JCBACox10tm1CtmCox10tm1CtmTgCamk2acreSzi0TgCamk2acreSziCox10tm1Ctm