Juan I. Garaycoechea, et.al., Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function., Nature, 2012, 489

http://rdf.ncbi.nlm.nih.gov/pubmed/22922648

Juan I. Garaycoechea, et.al., Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function., Nature, 2012, 489

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased sensitivity to induced cell death_Fanca<tm1a(EUCOMM)Wtsi>/Fanca<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008943IC57BL6NFancatm1aEUCOMMWtsiFancatm1aEUCOMMWtsiFancatm1aEUCOMMWtsi
• increased sensitivity to induced cell death_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008943C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• thrombocytopenia_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0003179I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• anemia_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0001577I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased sensitivity to induced cell death_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008943I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased bone marrow cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000333I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal hematopoietic stem cell physiology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0010763I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased physiological sensitivity to xenobiotic_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008873I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased physiological sensitivity to xenobiotic_Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008873I129S4SvJaeFancd2tm1HouFancd2tm1HouFancd2tm1Hou
• increased physiological sensitivity to xenobiotic_Slx4<tm1a(EUCOMM)Wtsi>/Slx4<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008873C57BL6NSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsiSlx4tm1aEUCOMMWtsi
• decreased hemoglobin content_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002874I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• pancytopenia_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0005152I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased erythrocyte cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal spleen morphology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000689I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased leukocyte cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000221I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• abnormal thymus morphology_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000703I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased sensitivity to induced cell death_Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008943I129S4SvJaeFancd2tm1HouFancd2tm1HouFancd2tm1Hou
• extramedullary hematopoiesis_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000240I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased hematopoietic stem cell number_Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0004810I129S4SvJaeFancd2tm1HouFancd2tm1HouFancd2tm1Hou
• increased mean corpuscular volume_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0002590I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• decreased hematocrit_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0000208I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi
• increased physiological sensitivity to xenobiotic_Fanca<tm1a(EUCOMM)Wtsi>/Fanca<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0008873IC57BL6NFancatm1aEUCOMMWtsiFancatm1aEUCOMMWtsiFancatm1aEUCOMMWtsi
• decreased hematopoietic stem cell number_Aldh2<tm1a(EUCOMM)Wtsi>/Aldh2<tm1a(EUCOMM)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0004810I129S4SvJaeC57BL6JC57BL6NAldh2tm1aEUCOMMWtsiAldh2tm1aEUCOMMWtsiFancd2tm1HouFancd2tm1HouFancd2tm1HouAldh2tm1aEUCOMMWtsi