Cyrus. Khandanpour, et.al., The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice., Blood, 2012, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/22932805

Cyrus. Khandanpour, et.al., The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice., Blood, 2012, 120

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gfi1<tm6.1(GFI1)Tmo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468264
• Gfi1<tm5.1(GFI1*)Tmo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468263

class

http://purl.org/net/cito/citesAsAuthority

• Gfi1<tm6.1(GFI1)Tmo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468264
• Gfi1<tm5.1(GFI1*)Tmo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468263

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased monocyte cell number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0000220I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• decreased B cell number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0005017I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• myeloid hyperplasia_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm51GFI1TmoGfi1tm51GFI1TmoKrastm4TyjKrasTgMx1cre1Cgn0KrasKrastm4TyjGfi1tm51GFI1TmoTgMx1cre1Cgn
• decreased thymocyte number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0000715I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• premature death_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm51GFI1TmoGfi1tm51GFI1TmoKrastm4TyjKrasTgMx1cre1Cgn0KrasKrastm4TyjGfi1tm51GFI1TmoTgMx1cre1Cgn
• decreased granulocyte number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0000334I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• myeloid hyperplasia_Gfi1<tm6.1(GFI1)Tmo>/Gfi1<tm6.1(GFI1)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm61GFI1TmoGfi1tm61GFI1TmoKrastm4TyjKrasTgMx1cre1Cgn0TgMx1cre1CgnKrastm4TyjKrasGfi1tm61GFI1Tmo
• abnormal definitive hematopoiesis_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>
  http://metadb.riken.jp/0002123I129S1Sv129X1SvJC57BL6Gfi1tm51GFI1TmoGfi1tm51GFI1TmoGfi1tm51GFI1Tmo
• decreased neutrophil cell number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0000222I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• premature death_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<+>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm51GFI1TmoGfi1Krastm4TyjKrasTgMx1cre1Cgn0TgMx1cre1CgnGfi1tm51GFI1TmoGfi1Krastm4TyjKras
• abnormal mitosis_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<+>
  http://metadb.riken.jp/0004046I129S1Sv129X1SvJC57BL6Gfi1tm51GFI1TmoGfi1Gfi1Gfi1tm51GFI1Tmo
• increased hematopoietic stem cell number_Gfi1<tm1Tmo>/Gfi1<tm1Tmo>
  http://metadb.riken.jp/0004809I129S1Sv129X1SvJGfi1tm1TmoGfi1tm1TmoGfi1tm1Tmo
• premature death_Gfi1<tm6.1(GFI1)Tmo>/Gfi1<tm6.1(GFI1)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm61GFI1TmoGfi1tm61GFI1TmoKrastm4TyjKrasTgMx1cre1Cgn0TgMx1cre1CgnKrastm4TyjKrasGfi1tm61GFI1Tmo
• abnormal mitosis_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>
  http://metadb.riken.jp/0004046I129S1Sv129X1SvJC57BL6Gfi1tm51GFI1TmoGfi1tm51GFI1TmoGfi1tm51GFI1Tmo
• increased monocyte cell number_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>
  http://metadb.riken.jp/0000220I129S1Sv129X1SvJC57BL6Gfi1tm51GFI1TmoGfi1tm51GFI1TmoGfi1tm51GFI1Tmo
• abnormal definitive hematopoiesis_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<+>
  http://metadb.riken.jp/0002123I129S1Sv129X1SvJC57BL6Gfi1tm51GFI1TmoGfi1Gfi1Gfi1tm51GFI1Tmo
• myeloid hyperplasia_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<+>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010373I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm51GFI1TmoGfi1Krastm4TyjKrasTgMx1cre1Cgn0TgMx1cre1CgnGfi1tm51GFI1TmoGfi1Krastm4TyjKras