Tracie. Pennimpede, et.al., In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome., Developmental biology, 2012, 372

http://rdf.ncbi.nlm.nih.gov/pubmed/22995555

Tracie. Pennimpede, et.al., In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome., Developmental biology, 2012, 372

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic lethality during organogenesis, incomplete penetrance_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0011108I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• truncated notochord_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004714I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal digestive system morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0000462I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal renal/urinary system morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0000516I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal paraxial mesoderm morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0008029I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• absent caudal vertebrae_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004653I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal notochord morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0002825I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• anal atresia_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0003130I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• kinked neural tube_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0003400I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• decreased paraxial mesoderm size_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0012183I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• small sacral vertebrae_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004657I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal tail morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0002111I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• respiratory distress_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0001954I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal rostral-caudal axis patterning_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0005221I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• rectal atresia_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0011775I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• anal stenosis_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0009052I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal vertebral column morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004703I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal somite development_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0001688I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• hypospadia_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0003124I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• notochord degeneration_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004712I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal neural tube closure_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0003720I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0011087I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• spina bifida occulta_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0005297I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• abnormal lumbar vertebrae morphology_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0003049I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• caudal vertebral transformation_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0004614I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh
• rectourethral fistula_Gt(ROSA)26Sor<tm3(tetO-EGFP,-RNAi:T)Bgh>/Gt(ROSA)26Sor
  http://metadb.riken.jp/0011786I129S6SvEvTacC57BL6JC57BL6NCrNMRIGtROSA26Sortm3tetOEGFPRNAiTBghGtROSA26SorGtROSA26SorGtROSA26Sortm3tetOEGFPRNAiTBgh

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal tail morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014568
• abnormal somite development in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014566
• embryonic lethality during organogenesis, incomplete penetrance in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014587
• anal stenosis in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014585
• caudal vertebral transformation in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014575
• kinked neural tube in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014573
• abnormal paraxial mesoderm morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014584
• abnormal vertebral column morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014578
• abnormal renal/urinary system morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014565
• neonatal lethality, complete penetrance in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014586
• abnormal digestive system morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014564
• abnormal mesenchyme morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014583
• abnormal rostral-caudal axis patterning in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014581
• hypospadia in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014571
• truncated notochord in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014580
• absent caudal vertebrae in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014576
• abnormal neural tube closure in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014574
• spina bifida occulta in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014582
• abnormal notochord morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014569
• rectourethral fistula in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014589
• anal atresia in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014572
• abnormal lumbar vertebrae morphology in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014570
• notochord degeneration in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014579
• small sacral vertebrae in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014577
• respiratory distress in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014567
• rectal atresia in RBRC05479
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014588