Prapaporn. Pisitkun, et.al., Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis., Immunity, 2012, 37

http://rdf.ncbi.nlm.nih.gov/pubmed/23123062

Prapaporn. Pisitkun, et.al., Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis., Immunity, 2012, 37

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Traf3ip2<tm2Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5462251

class

http://purl.org/net/cito/citesAsAuthority

• Traf3ip2<tm2Sbn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5462251

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• glomerulonephritis_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0002743I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• increased anti-double stranded DNA antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0004762I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• increased plasma cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0008097I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• decreased survivor rate_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0008770I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased monocyte cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0000220I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased double-negative T cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0005090I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• decreased survivor rate_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008770I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased IgG level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0002493I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased germinal center B cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<tm2Sbn>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008177I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2tm2SbnCd79atm1creRethCd79aTraf3ip2tm2SbnFcgr2btm1TtkCd79atm1creRethCd79a
• increased anti-nuclear antigen antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0004794I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased plasma cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<tm2Sbn>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0008097I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2tm2SbnCd79atm1creRethCd79aTraf3ip2tm2SbnFcgr2btm1TtkCd79atm1creRethCd79a
• increased anti-double stranded DNA antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0004762I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased spleen weight_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0004952I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2Traf3ip2Traf3ip2tm2SbnFcgr2btm1Ttk
• kidney inflammation_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0001859I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• abnormal neutrophil morphology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0005065I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased autoantibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0003725I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0002083I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased memory T cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008049I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased germinal center B cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008177I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2Traf3ip2Traf3ip2tm2SbnFcgr2btm1Ttk
• increased anti-nuclear antigen antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0004794I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• increased anti-double stranded DNA antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0004762I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• decreased survivor rate_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0008770I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• abnormal T cell morphology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008037I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased plasma cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0008097I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• glomerulonephritis_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<tm2Sbn>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002743I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2tm2SbnCd79atm1creRethCd79aTraf3ip2tm2SbnFcgr2btm1TtkCd79atm1creRethCd79a
• abnormal T cell morphology_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0008037I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased susceptibility to systemic lupus erythematosus_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0004801I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased single-positive T cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008082I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased myeloid dendritic cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008121I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• kidney inflammation_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0001859I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased plasma cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008097I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased plasmacytoid dendritic cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008524I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased anti-nuclear antigen antibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0004794I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased double-negative T cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0005090I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• increased spleen germinal center number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008481I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased autoantibody level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0003725I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• increased spleen germinal center number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0008481I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• decreased inflammatory response_Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0001876I129C57BL6Traf3ip2tm1SbnTraf3ip2tm1SbnTraf3ip2tm1Sbn
• decreased survivor rate_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0008770I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• enlarged spleen_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0000691I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2Traf3ip2Traf3ip2tm2SbnFcgr2btm1Ttk
• increased double-negative T cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0005090I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• increased IgG level_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0002493I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• premature death_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0002083I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased spleen germinal center number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<+>
  http://metadb.riken.jp/0008481I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17aIl17atm1YiwIl17aFcgr2btm1Ttk
• spleen hyperplasia_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0000693I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2Traf3ip2Traf3ip2tm2SbnFcgr2btm1Ttk
• decreased susceptibility to systemic lupus erythematosus_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Il17a<tm1Yiw>/Il17a<tm1Yiw>
  http://metadb.riken.jp/0004802I129P2OlaHsd129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkIl17atm1YiwIl17atm1YiwIl17atm1YiwFcgr2btm1Ttk
• increased neutrophil cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0000219I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2Traf3ip2Traf3ip2tm1SbnFcgr2btm1Ttk
• decreased susceptibility to systemic lupus erythematosus_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm1Sbn>/Traf3ip2<tm1Sbn>
  http://metadb.riken.jp/0004802I129129S4SvJaeC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm1SbnTraf3ip2tm1SbnFcgr2btm1TtkTraf3ip2tm1Sbn
• increased plasma cell number_Fcgr2b<tm1Ttk>/Fcgr2b<tm1Ttk>,Traf3ip2<tm2Sbn>/Traf3ip2<+>
  http://metadb.riken.jp/0008097I129S4SvJaeBALBcC57BL6Fcgr2btm1TtkFcgr2btm1TtkTraf3ip2tm2SbnTraf3ip2Traf3ip2Traf3ip2tm2SbnFcgr2btm1Ttk