Marta. Derecka, et.al., Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity., Cell metabolism, 2012, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/23217260

Marta. Derecka, et.al., Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity., Cell metabolism, 2012, 16

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal brown adipose tissue morphology_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0002971EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• increased cholesterol level_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0003982EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• abnormal mitochondrial physiology_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0006036EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• increased circulating free fatty acid level_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0001554EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• impaired adaptive thermogenesis_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0011049EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• obese_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0001261EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• increased circulating insulin level_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0002079EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• abnormal body temperature homeostasis_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0001777EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• abnormal fat cell differentiation_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0011168EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• increased body weight_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0001260EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• decreased energy expenditure_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0004890EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• disorganized mitochondrial cristae_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0011636EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd
• impaired glucose tolerance_Tyk2<tm1Shmd>/Tyk2<tm1Shmd>
  http://metadb.riken.jp/0005293EI129129P2OlaHsdorI129P2OlaHsdC57BL6Tyk2tm1ShmdTyk2tm1ShmdTyk2tm1Shmd