Oliver M. Dovey, et.al., Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice., Blood, 2013, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/23287868

Oliver M. Dovey, et.al., Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice., Blood, 2013, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hdac1<tm1.1Shmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5485390
• Hdac2<tm1.1Shmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5485392

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000691I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• enlarged spleen_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000691I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• enlarged thymus_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000709I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• enlarged thymus_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000709I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased thymocyte number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000714I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• decreased thymocyte number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0000715I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
他29件を見る
• enlarged chest_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001267I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• enlarged chest_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001267I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• distended abdomen_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001270I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• distended abdomen_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001270I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• thymus hypoplasia_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001823I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• arrested T cell differentiation_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001825I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• arrested T cell differentiation_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0001825I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased tumor incidence_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002020I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased tumor incidence_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002020I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased T cell derived lymphoma incidence_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002024I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• premature death_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• premature death_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0002083I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• aneuploidy_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0004024I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• trisomy_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0004027I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased double-negative T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005090I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased double-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005091I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased double-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005091I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• decreased double-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• decreased double-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005092I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased T cell proliferation_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005348I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased pulmonary respiratory rate_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005573I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased pulmonary respiratory rate_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0005573I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• decreased CD4-positive, alpha beta T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008075I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• decreased CD8-positive, alpha-beta T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008079I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased single-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<+>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008082I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2TgLckcre1Cwi0Hdac2Hdac1tm11ShmcHdac2tm11ShmcTgLckcre1Cwi
• increased single-positive T cell number_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008082I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• chromosomal instability_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0008866I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• increased thymocyte apoptosis_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0009541I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi
• abnormal thymus corticomedullary boundary morphology_Hdac1<tm1.1Shmc>/Hdac1<tm1.1Shmc>,Hdac2<tm1.1Shmc>/Hdac2<tm1.1Shmc>,Tg(Lck-cre)1Cwi/0
  http://metadb.riken.jp/0009543I129S7SvEvBrdHdac1tm11ShmcHdac1tm11ShmcHdac2tm11ShmcHdac2tm11ShmcTgLckcre1Cwi0Hdac2tm11ShmcHdac1tm11ShmcTgLckcre1Cwi

class

http://purl.org/net/cito/citesAsAuthority

• Hdac1<tm1.1Shmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5485390
• Hdac2<tm1.1Shmc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5485392