Supriya. Sen, et.al., Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function., Nature communications, 2013, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/23299886

Supriya. Sen, et.al., Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function., Nature communications, 2013, 4

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating aspartate transaminase level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005343IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal hepatobiliary system development_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003943IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased liver glycogen level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010398IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased circulating HDL cholesterol level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000186IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal liver morphology_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000598IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased liver cholesterol level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0010026IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• postnatal lethality, incomplete penetrance_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0011086IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased body size_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001265IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased insulin sensitivity_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002891IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal endoplasmic reticulum morphology_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009378IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal hepatocyte morphology_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal thymus development_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000704IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased circulating cholesterol level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005179IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased circulating insulin-like growth factor I level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004701IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased circulating alanine transaminase level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal kidney development_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000527IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased hepatocyte apoptosis_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003887IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• perinatal lethality, incomplete penetrance_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0011090IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased liver triglyceride level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009356IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased fatty acid oxidation_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0014172IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased brown adipose tissue amount_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001780IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased circulating triglyceride level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002644IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal bile canaliculus morphology_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008991IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• pale liver_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000603IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased circulating serum albumin level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005419IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• hypoglycemia_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000189IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased circulating alkaline phosphatase level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002968IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal liver sinusoid morphology_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008989IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased circulating bilirubin level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• small liver_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000601IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• decreased susceptibility to diet-induced obesity_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005659IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• increased circulating growth hormone level_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005123IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn
• abnormal glucose tolerance_Srsf3<tm1Pjln>/Srsf3<tm1Pjln>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005291IBALBcC57BL6DBASrsf3tm1PjlnSrsf3tm1PjlnTgAlbcre21Mgn0Srsf3tm1PjlnTgAlbcre21Mgn